MULTISPECIES: glucose-1-phosphate thymidylyltransferase RfbA

LOCUS       WP_004175258             289 aa            linear   BCT 09-DEC-2024
            [Enterobacteriaceae].
ACCESSION   WP_004175258
VERSION     WP_004175258.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 289)
  AUTHORS   Ma,Y., Mills,J.A., Belisle,J.T., Vissa,V., Howell,M., Bowlin,K.,
            Scherman,M.S. and McNeil,M.
  TITLE     Determination of the pathway for rhamnose biosynthesis in
            mycobacteria: cloning, sequencing and expression of the
            Mycobacterium tuberculosis gene encoding
            alpha-D-glucose-1-phosphate thymidylyltransferase
  JOURNAL   Microbiology (Reading) 143 (Pt 3), 937-945 (1997)
   PUBMED   9084178
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01207.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..289
                     /gene="rfbA"
     Protein         1..289
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=31859
     Region          2..286
                     /region_name="rmlA"
                     /note="glucose-1-phosphate thymidylyltransferase, short
                     form; TIGR01207"
                     /db_xref="CDD:130274"
     Site            order(6,8..9,80,83..86,108,144,159..160,170,198)
                     /site_type="active"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133019"
     Site            order(12,15..17,20..21,25..27,29..32,35,60,112..113,
                     135..138,142..143,221..223,227..228,231,234..236,239..240)
                     /site_type="active"
                     /note="tetramer interface [active]"
                     /db_xref="CDD:133019"
ORIGIN      
        1 mkgivlaggs gtrlypitqg vskqllpiyd kpmifypvsv lmlagirdil iistpddmps
       61 fqrllgdgsq fgvnfsyaiq pspdglaqaf iigekfignd acalvlgdni yfgqsfgkkl
      121 eaaaaktsga tvfgyqvldp erfgvvefde nfkalsieek plkpksdwav tglyfydnnv
      181 vemakdvkps ergeleittl nqmylergdl qvellgrgfa wldtgthdsl ieasqfihti
      241 ekrqgmkvac leeiayrnqw lsaegvaaqa erlkkteyga ylkrllsed