MULTISPECIES: alpha-keto acid decarboxylase family protein

LOCUS       WP_004159719             553 aa            linear   BCT 31-DEC-2024
            [Klebsiella].
ACCESSION   WP_004159719
VERSION     WP_004159719.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Pohl,M., Lingen,B. and Muller,M.
  TITLE     Thiamin-diphosphate-dependent enzymes: new aspects of asymmetric
            C-C bond formation
  JOURNAL   Chemistry 8 (23), 5288-5295 (2002)
   PUBMED   12432496
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Hawkins,C.F., Borges,A. and Perham,R.N.
  TITLE     A common structural motif in thiamin pyrophosphate-binding enzymes
  JOURNAL   FEBS Lett 255 (1), 77-82 (1989)
   PUBMED   2792374
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11467699
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..553
                     /product="alpha-keto acid decarboxylase family protein"
                     /EC_number="4.1.1.-"
                     /GO_function="GO:0016831 - carboxy-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /calculated_mol_wt=59858
     Region          1..545
                     /region_name="PDC1"
                     /note="TPP-dependent 2-oxoacid decarboxylase, includes
                     indolepyruvate decarboxylase [Carbohydrate transport and
                     metabolism, Coenzyme transport and metabolism, General
                     function prediction only]; COG3961"
                     /db_xref="CDD:443161"
ORIGIN      
        1 mqptytigdy lldrlvdcgi drlfgvpgdy nlqfldrvia hsalgwvgca nelnaayaad
       61 gyarikgaga llttygvgel salngiagsy aehipvlhiv gapstgaqqr gellhhtlgd
      121 gdfrhfarms eqitcsqall tagnacheid rvlrdmlthh rpgylmlpad varaaaiapa
      181 qrllvepapa denqlagfce hasrllrgsr rislladfla qryglqktlr ewvaktpvah
      241 atmlmgkglf deqqsgfvgt ysgiasapqt reaienadti icigtrftdt itagftqhla
      301 rektieiqpf avrvgdhwfs gvpmdkalaa lmtlsaplaa ewatpqvvap eaeegaegel
      361 tqknfwatvq galrpgdiil adqgtaafgi aalklpseas livqplwgsi gftlpaayga
      421 qtaaaerrvv livgdgaaql tiqemgsmlr dkqkplilll nnegytvera ihgpeqrynd
      481 ialwdwqrlp eafapdvasr crrvtqtsel reamtesits dtltlvevml pkmdipdflr
      541 avtqaleern srv