MULTISPECIES: MFS transporter [Enterobacteriaceae].

LOCUS       WP_004153321             479 aa            linear   BCT 08-FEB-2025
ACCESSION   WP_004153321
VERSION     WP_004153321.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023745
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..479
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=53191
     Region          16..464
                     /region_name="MFS_MelB_like"
                     /note="Salmonella enterica Na+/melibiose symporter MelB
                     and similar transporters of the Major Facilitator
                     Superfamily; cd17332"
                     /db_xref="CDD:340890"
     Site            order(26..27,30..31,34,67,127..128,130..132,135,156,
                     159..160,163,266,269..270,273..275,278,305,309,364..365,
                     369,373,396,399..400,403..404,407)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340890"
ORIGIN      
        1 mhsrhdeyhk ltrgerigyg mgdfaqnlvf gtiggflalh mltvntista tagfiflfvr
       61 iinvfwdpmv gtyvdkrtsk agkyrpwllr agvplvilsa llfapipgvk gsvafafiiy
      121 laldlvyslv nipygslnas ltrdpesidk ltstrmmlan sanllvytlf pmfvqmaapk
      181 drslkdtgff glelnlgnyt dpsanyawfg vyaiymiiga valficykct kervvataeq
      241 tanvkttdlf helrhnrplv ilgmffmlaf tfmffmntvn gffnqfvvgh sewmgavglv
      301 asipgiafpv fwpklkkifg kkgffhlfla mfivgellty vwsregmhda lwlayiatfi
      361 kqwgltsatg fmwalvpevi aygelksgkr naaiinaimg lffkigftig gaiplwllav
      421 ygfnesgavq sasaidgiim tavwipiala aismvimqvy pisdkhvtdi nrqldeirv