MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004152361             405 aa            linear   BCT 28-JUL-2024
ACCESSION   WP_004152361
VERSION     WP_004152361.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..405
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=40696
     Region          19..388
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(29..30,33..34,37,69,119..120,122..124,127,147,
                     150..151,154,222,225..226,229..231,234,262,266,318..319,
                     323,327,342,345..346,349..350,353)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mkeialplhp aparvwiavv algicafsiv tselapvgml salaadfhqt esgvglavta
       61 ygwvgalaal lsgamparis rkallvglml ilafsclaat rsysmfalms armigalahg
      121 afwaligiva aqlvpphrlg lataiifggv saasvvgvpl asfiatlagw rlafmsmall
      181 slaaaavlcs tlpplaapap vrlrvyrdif rnpllgglyg ataciitahf aaftyiesll
      241 inlqgvpata lsgllllsgv sgllgnviag klidrhlkgl ifaalllsgg alallgaarl
      301 aplpfcfsgl llalwgagia ivfvglqtwl lrsagavaqp asaiyvaifn aaigtgafvg
      361 gqliasagls gmvwlaagim vgstlliall kaplpgqiga ataga