MULTISPECIES: Y-family DNA polymerase [Klebsiella].

LOCUS       WP_004152360             421 aa            linear   BCT 28-JUL-2024
ACCESSION   WP_004152360
VERSION     WP_004152360.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Tonzi,P. and Huang,T.T.
  TITLE     Role of Y-family translesion DNA polymerases in replication stress:
            Implications for new cancer therapeutic targets
  JOURNAL   DNA Repair (Amst) 78, 20-26 (2019)
   PUBMED   30954011
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Yang,W.
  TITLE     An overview of Y-Family DNA polymerases and a case study of human
            DNA polymerase eta
  JOURNAL   Biochemistry 53 (17), 2793-2803 (2014)
   PUBMED   24716551
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11480002
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..421
                     /product="Y-family DNA polymerase"
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006974 - DNA damage response [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0019985 - translesion synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0042276 - error-prone translesion
                     synthesis [Evidence IEA]"
                     /calculated_mol_wt=47168
     Region          1..421
                     /region_name="umuC"
                     /note="translesion error-prone DNA polymerase V subunit
                     UmuC; PRK03609"
                     /db_xref="CDD:179607"
     Site            order(6..7,10..11,42,45,100..101,153)
                     /site_type="active"
                     /db_xref="CDD:176454"
     Site            order(98,101,184..190,219,244..249,276,295..299,301)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176454"
ORIGIN      
        1 mfahcdvnaf yascqtafrp dlkgrpvvvl snndgcviar saeakpfvkm gepyfkqkaa
       61 flrhgvvafs snyelyadms srvmatleel tprceiysid eafcdvsgvr hcrdltdfgr
      121 eiratvlqrt hltlgvgiaq tktlaklanh aakqwprqtg gvvdlscpqr qrklmallpv
      181 sevwgigrri gkkleamgig tvlqlaesdi rfirkhftvv lertvrelrg epclaleefa
      241 pakqeiicsr sfgdritaye dmrqaicsya araaeklrge hqycrfvsaf vktspfalne
      301 pyygnsaslk lltptqdsrd iiaaatscld aiwkaghryq kagvmlgdfy sqgvaqlnlf
      361 delaprhnsa rlmqvldqln akngrgalyf agqgiqqqwq mkremlspry ttrygdllrv
      421 r