MULTISPECIES: aldo/keto reductase [Klebsiella].

FASTA View on NCBI
LOCUS       WP_004152141             289 aa            linear   BCT 25-JUL-2024
ACCESSION   WP_004152141
VERSION     WP_004152141.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 289)
  AUTHORS   Hyndman,D., Bauman,D.R., Heredia,V.V. and Penning,T.M.
  TITLE     The aldo-keto reductase superfamily homepage
  JOURNAL   Chem Biol Interact 143-144, 621-631 (2003)
   PUBMED   12604248
REFERENCE   2  (residues 1 to 289)
  AUTHORS   Jez,J.M., Bennett,M.J., Schlegel,B.P., Lewis,M. and Penning,T.M.
  TITLE     Comparative anatomy of the aldo-keto reductase superfamily
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 625-636 (1997)
   PUBMED   9307009
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 14442695
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..289
                     /product="aldo/keto reductase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=32125
     Region          6..263
                     /region_name="AKR_AKR5F1"
                     /note="the AKR5F family of aldo-keto reductase (AKR);
                     cd19133"
                     /db_xref="CDD:381359"
     Site            order(18..20,44,48..49,78,112..113,140..141,162,188..194,
                     204,216,231..236,239,242..243)
                     /site_type="active"
                     /db_xref="CDD:381359"
     Site            order(44,49,78,112)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381359"
ORIGIN      
        1 meysvlsnar kmpmlgfgvf kvtdkaeckq avlnairtgy rlidtaavyd nedavgeavr
       61 eaiaeglctr ealfitsklw vqdmantgma kagiaaslkk sgleyfdlyl lhqamgdyfs
      121 awraleeaye agtlkaigvs nfyphvlanf cetvrikpmv nqvelhpyfa qpaaleamkh
      181 yhvqpeawap lgggrhnpyq dallrgiada hqktiaqvvl rwnvqrgvtv ipkstrqeri
      241 eenfaiwdfv ltdnemaqis aldlgyvgea vkhfnpefvr gclgvkihd