MULTISPECIES: alpha-2-macroglobulin family protein [Klebsiella].

LOCUS       WP_004151984            1649 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_004151984
VERSION     WP_004151984.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 1649)
  AUTHORS   Arimura,Y. and Funabiki,H.
  TITLE     Structural Mechanics of the Alpha-2-Macroglobulin Transformation
  JOURNAL   J Mol Biol 434 (5), 167413 (2022)
   PUBMED   34942166
REFERENCE   2  (residues 1 to 1649)
  AUTHORS   Wong,S.G. and Dessen,A.
  TITLE     Structure of a bacterial alpha2-macroglobulin reveals mimicry of
            eukaryotic innate immunity
  JOURNAL   Nat Commun 5, 4917 (2014)
   PUBMED   25221932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1649)
  AUTHORS   Halaby,D.M., Poupon,A. and Mornon,J.
  TITLE     The immunoglobulin fold family: sequence analysis and 3D structure
            comparisons
  JOURNAL   Protein Eng 12 (7), 563-571 (1999)
   PUBMED   10436082
REFERENCE   4  (residues 1 to 1649)
  AUTHORS   Smith,D.K. and Xue,H.
  TITLE     Sequence profiles of immunoglobulin and immunoglobulin-like domains
  JOURNAL   J Mol Biol 274 (4), 530-545 (1997)
   PUBMED   9417933
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11457182
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..1649
                     /product="alpha-2-macroglobulin family protein"
                     /GO_function="GO:0004866 - endopeptidase inhibitor
                     activity [Evidence IEA]"
                     /GO_process="GO:0010951 - negative regulation of
                     endopeptidase activity [Evidence IEA]"
                     /calculated_mol_wt=178872
     Region          41..1649
                     /region_name="YfaS"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; COG2373"
                     /db_xref="CDD:441940"
ORIGIN      
        1 mkpfrlaals lalltafslt gcddsgtpqa sapapaadsn pgatakpdra qlaalaeksq
       61 gkaltlldas evqldgaatl vltfsvplqp dqdfsrsvhl vdkksgkvdg awelapnlke
      121 lrlrhlepkr elivsvdptl talnkatldk pfektlttrd iapsvgfasr gsllpgnvva
      181 glpvmalnvd nvdvnffrik peslsafvsq weyrnslsnw esdellkmad lvytgrfdln
      241 parntrekll lplsdikplq qpgvyvavmn pagrysysna atlftlsdig vsahryhnrl
      301 dvftqsleng aaqsgievql lnakgqtlae aksdsqghvt lqtdkeaall larkegqttl
      361 ldlklpaldl aefsiagapg fskqffmfgp rdlyrpgetv ilnallrdsd gkplaeqpvk
      421 levvqpdgqv irsvmskpvn glyqftypld sgaatgmwhi rasagdnqpr ewdfhvedfm
      481 permalnltp qaapvapdad vtfgvsgayl ygapasgnql qgklflrplr davaalpgfq
      541 fgdiaeenls rsldevqltl dekghgevtt ssqwqdshsp lqvvlqasll esggrpvtrt
      601 vkqpiwpaea lpgirpqftl kdvydyrtdt tvkqpvvden snaafdivya dvkgekkais
      661 glqvrlirer rdyywnwsds egwqsqfdqk dlqegeesld lqagqigkvs fpvewgsyrl
      721 evkgpddvvs svrfwagysw qdnsegagaa rpdrvtmkld kpsykpgdti rlhiaapaag
      781 kgyamvesse gplwwqeidv paegmdlsip vdktwnrhdl ylstlvvrpg dksrsatpkr
      841 avgllhlplg denrrltlal eapdkirpnq pltvkvkasv kegeapkqvn vllsavdsgv
      901 lnitdyatpd pwnaffgqkr ygadiydiyg qviegqgrva slrfggdgde lkrggkppvn
      961 hvtivaqqaq pvvlndqgeg tvtlpigdfn gelrvmaqaw taddfgssed kvvvaapvia
     1021 elntprflas gdttrlaldl snltdkpqtl qvhltasglv tlsegqlppv qlapgarstl
     1081 fipvsalagf gdgqvnasis glslpgetfa plqkqwkigv rpaypaqtvn sgavlqpges
     1141 wqppaaqsqg fapqtlqgql llsgkpplnl aryirelkay pygcleqtas glfpslytsa
     1201 aqlkalgisg dsdekrraai dvgisrllqm qlenggfalw dregpeeywl tayamdflvr
     1261 aseqgysvpv nainkgnerl lrylqepglm tvrysddaqa srfaaqayaa lvlarqqkap
     1321 lgalreiwsr hdqarsglpl lqlgialktm gdaprgdaal klavatprqd enrwlgdygs
     1381 plrdnalkla lleenkllpe vqnqllstls eeaygqrwls tqetnalfla grtladlpgs
     1441 wqaktslqae plagdkaqtr nldgdrlaal qvsntgsqpl wlrldssgyp qsapqpggnv
     1501 lgieraifdt hgqqksltsl rsgelvlvkl evtakrnvpd alvvdllpag lelenqnlan
     1561 ssaslqengd avqnllnqmq qadiqhiefr ddrfvaavav negqpvtlvy laravtpgty
     1621 qvpqpqvesm yapqwratga asgpltvtp