MULTISPECIES: efflux RND transporter permease subunit [Klebsiella].

LOCUS       WP_004151828            1030 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004151828
VERSION     WP_004151828.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 1030)
  AUTHORS   Nikaido,H. and Takatsuka,Y.
  TITLE     Mechanisms of RND multidrug efflux pumps
  JOURNAL   Biochim Biophys Acta 1794 (5), 769-781 (2009)
   PUBMED   19026770
REFERENCE   2  (residues 1 to 1030)
  AUTHORS   Tseng,T.T., Gratwick,K.S., Kollman,J., Park,D., Nies,D.H.,
            Goffeau,A. and Saier,M.H. Jr.
  TITLE     The RND permease superfamily: an ancient, ubiquitous and diverse
            family that includes human disease and development proteins
  JOURNAL   J Mol Microbiol Biotechnol 1 (1), 107-125 (1999)
   PUBMED   10941792
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11436314
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..1030
                     /product="efflux RND transporter permease subunit"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0042908 - xenobiotic transport [Evidence
                     IEA]"
                     /calculated_mol_wt=111261
     Region          1..1025
                     /region_name="AcrB"
                     /note="Multidrug efflux pump subunit AcrB [Defense
                     mechanisms]; COG0841"
                     /db_xref="CDD:440603"
ORIGIN      
        1 mltffirrpr famvialllt fvgavslkli pveqypaitp pvvnvsaswp gasasdvaea
       61 iaapletqln gvdhmlymes tssdegtyrl sitfaagtda dlaaidvqnr vaqalaqlpa
      121 evqqngvqvr krasnllmgv slysplgtlt plfvsnyast qvrealarlp gvgevqmfga
      181 rdysmriwlr pdrmnalnit tddvaqalre qnvqgaagqv gtppvfngqq qtltinglgr
      241 lneaasfgei iirrgaqgql vrladvatie lgarsyssga qlngkasayl giyptptana
      301 lqvasavrae lnrlhtrfpa dltwevkfdt trfvaatike igvslaltll avvvvvslfl
      361 qswratlivv laipvsligt favlyllgys antlslfaii laltmvvdda ivvvenvetk
      421 maegldrlqa taqalrqiag pviattlvll avfvpvallp givgelyrqf avtlstaval
      481 sslvaltltp alcalllrpr parpaavwra fnrlldgtrd gygrlvgrmn rrpwlalaat
      541 vaagalvafs ftsmpkgflp qedqgylfas vqlpeaasle rteavmaqar kllmanpave
      601 dviqvsgfni lngtsasngg fisvmlkdwh qrppldavma diqrqllslp eatimtfapp
      661 tlpglgnasg fdlrilaqag qssaeleqvt reilqlanqh sqlsrvfttw ssnvpqltlt
      721 vdrdraalld vpvaqifssl qtafggtrag dfsrnnrvyh vvmqnemqwr eraeqisely
      781 vrsrdgervr lsnlvtitpt vgapfiqqyn qfpsvsvsgs aaegvssrta maameqilqa
      841 hlppgydyaw sgiswqeqqt gnqavwivla avamawlflv aqyeswtlpa svmlsvlfai
      901 ggallwlwta gyandvyvqi glvllialaa knailivefa rsrreeglsi vdaaregatr
      961 rfravmmtav sfiigimpmm latgagaqsr riigttvfsg mlvatmvgil fipslyvlfq
     1021 rmrewahrrg