MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004151822             475 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004151822
VERSION     WP_004151822.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..475
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50367
     Region          19..463
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(23..24,27..28,31,63,113..114,116..118,121,141,
                     144..145,148,279,282..283,286..288,291,319,323,379..380,
                     384,388,404,407..408,411..412,415)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mntsavspgr aglllllsgq mlplidtsit nvaldaitht laasatqlel ivalygvafa
       61 vclamgsklg dnygrrrlfm wgvalfgias llcgmansig allaartlqg agaalivpqi
      121 latlhvtlkg paharaisly ggiggiafiv gqmgggwlvs adiaglgwrn affinvpicl
      181 lvlalsrryv petrretpsr idwqgtlyla lilccllfpm algpelhwpl wlqlmlvavl
      241 pllfamrqsa lrqqqrgdhp llpprllqlt sirfgmaial lffgawsgfm fcmaltmqeg
      301 lgmapwqsgn sfialgvayf isalyaprli arysmgrill tglavqiagl lllcatfsrf
      361 gvatnaltlv pataligygq alivnsfyri gmrdisasda gagsailstl qqatlglgpa
      421 ilgslflala rrgggnypqa lidfllveva mmlllgaial wlrhhlnrqp atvas