MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004151784             462 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004151784
VERSION     WP_004151784.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..462
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48489
     Region          25..415
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(32..33,36..37,40,72,122..123,125..127,130,150,
                     153..154,157,280,283..284,287..289,292,320,324,376..377,
                     381,385,401,404..405,408..409,412)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mtlfssqpgd eglpgparar vmaaimtttl mgvfdgtmin ialpsmaqem qvpasiavwf
       61 angyllaaam tlaifaalaa rlgyrpvfla glttftltsl gcalankpev ligmrvlqgi
      121 ggaatlsiap ailrsvfpgr llgrilgfha lliasssaig pvlggtilht lswqwlfain
      181 ilpgtlalll avralprdai rmqapfdtvg ailsalllgs timaanslqn atsqfgslcw
      241 malaalsgma fiwqirrtgh pllppsmfkn erftlaafts mvafvsqgit fialpflfqs
      301 eygyspvvsa llftpwplgi vliaphagrw adtisapais tlglvifvvg lillatlpar
      361 psmwdiclrs lvcgigfgcf qspnnremls nvirehasya sgvlsimrtf gqclgaaava
      421 vllaadersi hvalwsaaaa savsvvvsas rlrkithpae tg