MULTISPECIES: nucleoside permease [Klebsiella].

LOCUS       WP_004151767             417 aa            linear   BCT 28-MAR-2023
ACCESSION   WP_004151767
VERSION     WP_004151767.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 417)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   3  (residues 1 to 417)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
REFERENCE   4  (residues 1 to 417)
  AUTHORS   Law,C.J., Maloney,P.C. and Wang,D.N.
  TITLE     Ins and outs of major facilitator superfamily antiporters
  JOURNAL   Annu Rev Microbiol 62, 289-305 (2008)
   PUBMED   18537473
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10017491
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..417
                     /product="nucleoside permease"
                     /GO_function="GO:0015506 - nucleoside:proton symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015858 - nucleoside transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46105
     Region          1..414
                     /region_name="2A0110"
                     /note="nucleoside transporter; TIGR00889"
                     /db_xref="CDD:129967"
     Site            order(14..15,18..19,22,55,106..107,109..111,114,136,
                     139..140,143,217,220..221,224..226,229,264,268,321..322,
                     326,330,346,349..350,353..354,357)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340866"
ORIGIN      
        1 mnlklqlkil sflqfclwgs wlttlgsymf vtlkfdgaai gavysslgia avlmptllgi
       61 vadkwisakw vyaichlvga ltlylaaqvt tpgemflvil lnslaymptl glintisyyr
      121 lqsagldivt dfppiriwgt igfilamwgv sfsgfelshm qlyigatlsv lltlftltlp
      181 hipvanaqrn qswaemlgln afalfknkrm aiffifsmml gaelqitnmf gntflhsfdk
      241 dplfagsfiv ehasvlmsis qisetlfilt ipfflsrygi knvmlisiva wmlrfglfaf
      301 gdptpfgtvl lvlsmivygc afdffnisgs vfvekevrpe irasaqgmfl mmtngfgcil
      361 ggmvsgkvve hftvegitdw qsvwlifagy slvlafafva lfkykhvrqp taaqqsv