MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004151719             400 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004151719
VERSION     WP_004151719.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 400)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024414
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..400
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=41703
     Region          15..377
                     /region_name="MFS_MosC_like"
                     /note="Membrane protein MosC and similar proteins of the
                     Major Facilitator Superfamily of transporters; cd17393"
                     /db_xref="CDD:340951"
     Site            order(24..25,28..29,32,64,117..118,120..122,125,144,
                     147..148,151,224,227..228,231..233,236,264,268,317..318,
                     322,326,341,344..345,348..349,352)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340951"
ORIGIN      
        1 mttqssrral qlrlwalfmf ffipgllmas watrtpaird llalstaemg vvlfglsvgs
       61 msgilcsawl vkrfgtrkvi rttmsfavlg mlvlslalwv tsaplfafgl aifgasfgsa
      121 evainvegaa ieremnktvl pmmhgfysfg tlfgagvgma vtgfglpaap hilaaalvai
      181 lpiaiairai pdgtgknaae vahgeakglp vwrdaqllli gvivlamafa egsandwlpl
      241 lmvdghgfsp tsgsliyagf tlgmtlgrft ggwfidrysr vavvrgsavm galgigliif
      301 vdnpwvagis vllwgigasl gfpltisaas dtgpdapkrv svvaitgyla flvgppllgf
      361 lgehfglrsa mmvvlglvmv aalvaravak pqsepvmens