MULTISPECIES: NmrA/HSCARG family protein [Klebsiella].

LOCUS       WP_004151593             303 aa            linear   BCT 23-JUL-2024
ACCESSION   WP_004151593
VERSION     WP_004151593.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 303)
  AUTHORS   Kavanagh,K.L., Jornvall,H., Persson,B. and Oppermann,U.
  TITLE     Medium- and short-chain dehydrogenase/reductase gene and protein
            families : the SDR superfamily: functional and structural diversity
            within a family of metabolic and regulatory enzymes
  JOURNAL   Cell Mol Life Sci 65 (24), 3895-3906 (2008)
   PUBMED   19011750
REFERENCE   2  (residues 1 to 303)
  AUTHORS   Oppermann,U., Filling,C., Hult,M., Shafqat,N., Wu,X., Lindh,M.,
            Shafqat,J., Nordling,E., Kallberg,Y., Persson,B. and Jornvall,H.
  TITLE     Short-chain dehydrogenases/reductases (SDR): the 2002 update
  JOURNAL   Chem Biol Interact 143-144, 247-253 (2003)
   PUBMED   12604210
REFERENCE   3  (residues 1 to 303)
  AUTHORS   Stammers,D.K., Ren,J., Leslie,K., Nichols,C.E., Lamb,H.K.,
            Cocklin,S., Dodds,A. and Hawkins,A.R.
  TITLE     The structure of the negative transcriptional regulator NmrA
            reveals a structural superfamily which includes the short-chain
            dehydrogenase/reductases
  JOURNAL   EMBO J 20 (23), 6619-6626 (2001)
   PUBMED   11726498
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10142859
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..303
                     /product="NmrA/HSCARG family protein"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /calculated_mol_wt=32151
     Region          7..232
                     /region_name="NmrA_like_SDR_a"
                     /note="NmrA (a transcriptional regulator) and HSCARG (an
                     NADPH sensor) like proteins, atypical (a) SDRs; cd05251"
                     /db_xref="CDD:187561"
     Site            order(11,13..16,36,78..79,81,115,131,150..153)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:187561"
     Site            order(127,131)
                     /site_type="active"
                     /db_xref="CDD:187561"
     Site            192
                     /site_type="other"
                     /note="regulatory binding site [polypeptide binding]"
                     /db_xref="CDD:187561"
ORIGIN      
        1 mnnaqtvlvf gatgqqggsv arallhrgwr vralvrdpfs agaaalaarg aelvvgtfed
       61 raamrsamag vdgvfsvqps spggtvtdeq evrygitiad lavecgvkhl vyssgsatge
      121 tptgvahydt kaeierhirr lplaativrp atfmellvmp gfgldegrfq ffmlpegrmq
      181 vlavedighl vaavfaapar fagktfeias dsvtgrqlev lfsaaagrpi pysrfsdevl
      241 aaspflhklt glvddgrlag hadldalrql hpqlhtfagw lagpgrpafe raltsgarwa
      301 fdr