MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004151570             440 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004151570
VERSION     WP_004151570.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024289
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..440
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47414
     Region          16..422
                     /region_name="MFS_ShiA_like"
                     /note="Shikimate transporter and similar proteins of the
                     Major Facilitator Superfamily; cd17369"
                     /db_xref="CDD:340927"
     Site            order(29..30,33..34,37,76,134..135,137..139,161,164..165,
                     168,250,253..254,257..259,262,290,294,347..348,352,356,
                     372,375..376,379..380,383)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340927"
ORIGIN      
        1 msnpqdntas ilqknkkvli asltgsaiew fdyflygtaa alvfnkiffp mvdpviglil
       61 swlsfsltff irpiggvifa higdrigrkk tlvltlslmg satvaigllp tyemvglwap
      121 allitlriiq gmgiggewgg allayeyape krkgffgsip qagvtigmlm atfivslmtl
      181 fdeaqflawg wripfllssv lvflglwirk didetpafkq vkksgqvaka plrdtlkhhw
      241 revliaaglk vvetapfyif stfvvsyatt tlsyqksqal esvtlgalva tvmiplmgll
      301 sdkvgrqkmy tlsvvllglf ivpwfllldt gtgwgimlat ivafgilwap vtavlgtlcs
      361 eifsanvryt gitlgyqlga alaggtapli atgllakydg dwrpvaiylg vtvaisllai
      421 fcasrmksal gtapsraesa