MULTISPECIES: MDR family MFS transporter [Klebsiella].

LOCUS       WP_004151512             497 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004151512
VERSION     WP_004151512.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 497)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 497)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 497)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024942
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..497
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=52745
     Region          30..415
                     /region_name="MFS_Azr1_MDR_like"
                     /note="Saccharomyces cerevisiae Azole resistance protein 1
                     (Azr1p), and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17502"
                     /db_xref="CDD:341045"
     Site            order(31..32,35,66,116..117,119..121,124,144,147..148,151,
                     276,279..280,283..285,288,316,320,373..374,378,382,398,
                     401..402,405..406,409)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341045"
ORIGIN      
        1 mtsqvanppv qsirllfsal llvmllsald qtivstalpt ivgelggldk lswvvtayil
       61 sstiavplyg kfgdlfgrki vlqvaiglfl vgsalcglaq nmtqlvlmrg lqglgggglm
      121 vismaavadv ippanrgryq glfggvfgla tvigpliggf lvqhaswrwi fyinlplglf
      181 allvigavfh ssnkrsqhqi dwlgaiylsm allciilfts eggsvhawnd pqlwcilafg
      241 ivgiigfiye ermaaepiip lalfrnrsfl lcsligfvig mslfgsvtfl plylqvvkea
      301 tpteaglqli plmgglllts iisgriisrt gkyrlfpilg tllgvtgmvl ltritihspl
      361 wqlylftgvl gaglglvmqv lvlavqnamp aqmygvatsg atlfrsiggs igvalfgavf
      421 thvlqsnlqq llpegavlpp gmnpvavqhl padirldyld afgaaihaaf lmaagimava
      481 fvlswllkea plktath