MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

LOCUS       WP_004151364             438 aa            linear   BCT 04-JUN-2024
            [Klebsiella].
ACCESSION   WP_004151364
VERSION     WP_004151364.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 438)
  AUTHORS   Kouidmi,I., Levesque,R.C. and Paradis-Bleau,C.
  TITLE     The biology of Mur ligases as an antibacterial target
  JOURNAL   Mol Microbiol 94 (2), 242-253 (2014)
   PUBMED   25130693
REFERENCE   2  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Martin,L., Fanchon,E., Blanot,D., Le
            Beller,D., van Heijenoort,J. and Dideberg,O.
  TITLE     Determination of the MurD mechanism through crystallographic
            analysis of enzyme complexes
  JOURNAL   J Mol Biol 289 (3), 579-590 (1999)
   PUBMED   10356330
REFERENCE   3  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Fanchon,E., Martin,L., Blanot,D., van
            Heijenoort,J. and Dideberg,O.
  TITLE     Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate
            ligase from Escherichia coli
  JOURNAL   EMBO J 16 (12), 3416-3425 (1997)
   PUBMED   9218784
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01087.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..438
                     /gene="murD"
     Protein         1..438
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /EC_number="6.3.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /calculated_mol_wt=46732
     Region          3..437
                     /region_name="MurD"
                     /note="UDP-N-acetylmuramoylalanine-D-glutamate ligase
                     [Cell wall/membrane/envelope biogenesis]; COG0771"
                     /db_xref="CDD:440534"
ORIGIN      
        1 madyqgkkvv iiglgmtgls cvdffmargv tprvmdtrva ppgldklpes vechvgglnd
       61 twllaadliv aspgialahp slsaaadagv eivgdielfc reaqapiiai tgsngkstvt
      121 tlvgemakaa gvnvgvggni glpalmlldt drelyvlels sfqlettssl qavaatilnv
      181 tedhmdrypl glqqyraakl riyenaktcv vnaddaltmp vrgadercis fgvdvgdyhl
      241 nrqqgetwlr vkgekvlnvk empltgqhny snalaalala daaglprass lkalttftgl
      301 ahrfqlvldh ngvrwindsk atnvgsteaa lnglqldgtl ylllggdgks adftplkryl
      361 ggdrirlycf grdgaelael rpevavqtet meqamrqiap lvkagdmvll spacasldqf
      421 knfeqrgemf arlakelg