MULTISPECIES: EAL domain-containing protein [Klebsiella].

LOCUS       WP_004151096             723 aa            linear   BCT 21-JAN-2025
ACCESSION   WP_004151096
VERSION     WP_004151096.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 723)
  AUTHORS   Chou,S.H. and Galperin,M.Y.
  TITLE     Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms
  JOURNAL   J Bacteriol 198 (1), 32-46 (2016)
   PUBMED   26055114
REFERENCE   2  (residues 1 to 723)
  AUTHORS   Schirmer,T. and Jenal,U.
  TITLE     Structural and mechanistic determinants of c-di-GMP signalling
  JOURNAL   Nat Rev Microbiol 7 (10), 724-735 (2009)
   PUBMED   19756011
REFERENCE   3  (residues 1 to 723)
  AUTHORS   Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U.
  TITLE     GGDEF and EAL domains inversely regulate cyclic di-GMP levels and
            transition from sessility to motility
  JOURNAL   Mol Microbiol 53 (4), 1123-1134 (2004)
   PUBMED   15306016
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10005623
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..723
                     /product="EAL domain-containing protein"
                     /EC_number="3.1.4.52"
                     /GO_function="GO:0071111 - cyclic-guanylate-specific
                     phosphodiesterase activity [Evidence IEA]"
                     /calculated_mol_wt=82017
     Region          160..723
                     /region_name="EAL"
                     /note="EAL domain, c-di-GMP-specific phosphodiesterase
                     class I (or its enzymatically inactive variant) [Signal
                     transduction mechanisms]; COG2200"
                     /db_xref="CDD:441802"
ORIGIN      
        1 mldkininik ktllafiicl vaiplarfis pqtiidgnli yiawlpisvm fsvififgry
       61 aiaplilafa itnsfliklt lpqafillfc qlfavfvsca ilrllvgkrw rcgptakhmg
      121 arifwggffa pvllkitmyl agqyfafpla itsyfgsmpl iytvidiqsl isaalifttf
      181 lyypmrmiis pryarrfwqq eclpwlapqy rsftlywfia laviltllca pyqsefiagy
      241 lvpvifivyf igisrighal lriswsvsaf llvvynknfl qgvqseysls fvlsvlisft
      301 iclfymadiy arsdrnkrrw rsqaeedplt glpnlrales hlqscpqqai cslridnldf
      361 lsrhyglmmg vdckrqiira lqpllgaadk vfqvpgseli lvldgpepss rlnhmvavln
      421 hkkfswhnqp ldlefgaawg rddgqgegly qmlgqlswls eqagserrvl aldeeqdlvv
      481 dqtteqvrll mrvkqvlkdr almlyaqpiq npegegyhei ltrmrcgdsv impdrfipli
      541 vqfnlsqrfd mlvletlfsm lhkhpgqrfs vnllpatlmq knsagqiial fqrysvspel
      601 itievteeqa fsnadtsrqn lealrafgca iaiddfgtgy anyerlkhlq adiikidgcf
      661 vrdiltdpld aimvksivem arakqmsvva eyvesepqka rllelgvnyl qgyligkpqp
      721 lge