MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004151071             473 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004151071
VERSION     WP_004151071.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..473
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50827
     Region          40..459
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(50..51,54..55,58,90,140..141,143..145,148,171,
                     174..175,178,286,289..290,293..295,298,327,331,387..388,
                     392,396,412,415..416,419..420,423)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mstlpvdnpg iasvpvssvg dvarlinsgk eqakyarmiv flalggvfld aydlttlsyg
       61 iddvvrefql splltglvts simvgtivgn iiggwltdky grysvfmadm fffvisaiaa
      121 glapnvwvli garflmgigv gidlpvamsy laefsrfagk gnkaarlaaw cpmwyaastv
      181 cfliifglyf llpqehldwl wrasllfgav palliiavrs rfmnesplwa anqgdltsav
      241 rilrdswgih ahevpaakpa papkvsfrvl fekpyrerti vagvmnicis feytaiaffl
      301 psilaqflga gvfetisasl glnalfaftg gllgmhlawk ypsrhvaiag falqfvaliv
      361 lalvgqphat agivlaiaml glwlfaegfg pgaqlmiypa lsyptairat gvgfsralsg
      421 igsalalfil pllqaslgtq mfwvvslaai ipiffllavr heptredida lhe