MULTISPECIES: outer membrane channel protein TolC [Klebsiella].

LOCUS       WP_004150921             489 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_004150921
VERSION     WP_004150921.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Raczkowska,A., Trzos,J., Lewandowska,O., Nieckarz,M. and
            Brzostek,K.
  TITLE     Expression of the AcrAB Components of the AcrAB-TolC Multidrug
            Efflux Pump of Yersinia enterocolitica Is Subject to Dual
            Regulation by OmpR
  JOURNAL   PLoS ONE 10 (4), e0124248 (2015)
   PUBMED   25893523
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Koronakis,V., Sharff,A., Koronakis,E., Luisi,B. and Hughes,C.
  TITLE     Crystal structure of the bacterial membrane protein TolC central to
            multidrug efflux and protein export
  JOURNAL   Nature 405 (6789), 914-919 (2000)
   PUBMED   10879525
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Koronakis,V., Li,J., Koronakis,E. and Stauffer,K.
  TITLE     Structure of TolC, the outer membrane component of the bacterial
            type I efflux system, derived from two-dimensional crystals
  JOURNAL   Mol. Microbiol. 23 (3), 617-626 (1997)
   PUBMED   9044294
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007002.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09465
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..489
                     /gene="tolC"
     Protein         1..489
                     /product="outer membrane channel protein TolC"
                     /GO_function="GO:0015562 - efflux transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=52909
     Region          1..449
                     /region_name="tolC"
                     /note="outer membrane channel protein; Reviewed; PRK09465"
                     /db_xref="CDD:236529"
ORIGIN      
        1 mkkllpilig lsltgfsams qaenllqvyq qarisnpdlr ksaadrdaaf ekinearspl
       61 lpqlglgady tytngyrdsn gvnsnvtsgs lqltqvlfdm skwraltlqe ktagiqdvty
      121 qtdqqtliln tatayfkvla aidtlsytea qkqaiyrqld qttqrfnvgl vaitdvqnar
      181 sqydavlane vtarndldna veglrqvtgn yypelaslnv ngfktnkpqa vnallkeaen
      241 rnlsllqarl sqdlareqir qaqdghlptl nlsastgvsn tryngsktnt playndsdng
      301 qnqiglnfsl plyqggavts qvkqaqynfv gaseqlesah rsvvqtvrss fnnvnasiss
      361 inaykqavvs aqssldamea gysvgtrtiv dvldatttly nakqqlsnar ynylinelni
      421 ksalgtlneq dlvalnntlg kpistsadsv apenpqqdat adgygnttaa vkpasarttq
      481 ssgsnpfrq