MULTISPECIES: trans-sulfuration enzyme family protein [Klebsiella].

LOCUS       WP_004150915             382 aa            linear   BCT 23-DEC-2024
ACCESSION   WP_004150915
VERSION     WP_004150915.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Mozzarelli,A. and Bettati,S.
  TITLE     Exploring the pyridoxal 5'-phosphate-dependent enzymes
  JOURNAL   Chem Rec 6 (5), 275-287 (2006)
   PUBMED   17109392
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Messerschmidt,A., Worbs,M., Steegborn,C., Wahl,M.C., Huber,R.,
            Laber,B. and Clausen,T.
  TITLE     Determinants of enzymatic specificity in the Cys-Met-metabolism
            PLP-dependent enzymes family: crystal structure of cystathionine
            gamma-lyase from yeast and intrafamiliar structure comparison
  JOURNAL   Biol Chem 384 (3), 373-386 (2003)
   PUBMED   12715888
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Christen,P. and Mehta,P.K.
  TITLE     From cofactor to enzymes. The molecular evolution of
            pyridoxal-5'-phosphate-dependent enzymes
  JOURNAL   Chem Rec 1 (6), 436-447 (2001)
   PUBMED   11933250
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Mehta,P.K. and Christen,P.
  TITLE     The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes
  JOURNAL   Adv Enzymol Relat Areas Mol Biol 74, 129-184 (2000)
   PUBMED   10800595
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10001832
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..382
                     /product="trans-sulfuration enzyme family protein"
                     /GO_function="GO:0016846 - carbon-sulfur lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /calculated_mol_wt=41453
     Region          3..381
                     /region_name="MetC"
                     /note="Cystathionine beta-lyase/cystathionine
                     gamma-synthase [Amino acid transport and metabolism];
                     COG0626"
                     /db_xref="CDD:440391"
ORIGIN      
        1 mssihtlsvh sgtftdshga vmppiyatst faqpapgqht gyeysrsgnp trhaletaia
       61 dlengtrgya fasglaaist vlelldkdsh lvavddvygg tyrllenvrr rsaglqvswv
      121 kpddlagiea airpdtrmiw vetptnpllk ladlsaiaai arrhnlisva dntfaspaih
      181 rplehgfdiv vhsatkylng hsdvvaglav vgdnsglaek lgylqnavgg vldpfssflt
      241 lrgirtlalr merhsanalq laewleqqpe vervwfpwla shphhqlarq qmalpggmis
      301 vvvkgdegya eriisklrwf tlaeslggve slvsqpfsmt hasiplekrl angitpqlir
      361 lsvgiedphd liadwqqalr ae