MULTISPECIES: NAD-dependent succinate-semialdehyde dehydrogenase

LOCUS       WP_004150833             482 aa            linear   BCT 29-MAR-2023
            [Klebsiella].
ACCESSION   WP_004150833
VERSION     WP_004150833.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 482)
  AUTHORS   Marchitti,S.A., Brocker,C., Stagos,D. and Vasiliou,V.
  TITLE     Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase
            superfamily
  JOURNAL   Expert Opin Drug Metab Toxicol 4 (6), 697-720 (2008)
   PUBMED   18611112
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10162917
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..482
                     /product="NAD-dependent succinate-semialdehyde
                     dehydrogenase"
                     /EC_number="1.2.1.-"
                     /calculated_mol_wt=51309
     Region          30..480
                     /region_name="ALDH_F5_SSADH_GabD"
                     /note="Mitochondrial succinate-semialdehyde dehydrogenase
                     and ALDH family members 5A1 and 5F1-like; cd07103"
                     /db_xref="CDD:143421"
     Site            order(68,77,118,121..122,124..132,138..140,145,227,239,
                     243,246,303,307,353,421,423..424,428,430,433,435..441,447,
                     450..451,457,462,474..480)
                     /site_type="other"
                     /note="tetramerization interface [polypeptide binding]"
                     /db_xref="CDD:143421"
     Site            order(153..157,165,180,182..183,231..234,237,240..241,
                     255..257,289,386,388,414,452)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:143421"
     Site            order(157,255,286,289)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143421"
ORIGIN      
        1 msvfhsdlfr qqaliagswr daadgttlav snpstgatlg qipnmgraea qqavdaaaaa
       61 lpnwraftaa qraallknwh rlilenktal aqimtaeqgk plaeaegeia yaasfiewfa
      121 eqgkrangei ipspgadkrl mvirqgvgvc aaitpwnfpa amitrkagpa laagctmvik
      181 panetpftal amaelanqag ipqgvinvvt gqsreigavf tgdervrkls ftgstevgrv
      241 lmrqcaesik klslelggna pfivfddadi dkavegalia kfrnagqtcv cvnrfyihra
      301 iydqfcdkfv arvaalkvgd gsesdvqigp linadagrkv qsllddalsr gatlltggka
      361 hplggnfftp tvigdvqpgs lllqeeifgp vaalvkfdde qqvieqannt iyglasyfys
      421 ndaariwrvs eqleygmvgi ntglisneva pfggvkqsgl gregsehgie dylemkylcq
      481 gl