MULTISPECIES: sensor domain-containing diguanylate cyclase

LOCUS       WP_004150781             337 aa            linear   BCT 24-JUL-2024
            [Klebsiella].
ACCESSION   WP_004150781
VERSION     WP_004150781.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 337)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10005839
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..337
                     /product="sensor domain-containing diguanylate cyclase"
                     /EC_number="2.7.7.65"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=37547
     Region          <5..>337
                     /region_name="GAF"
                     /note="GAF domain [Signal transduction mechanisms];
                     COG2203"
                     /db_xref="CDD:441805"
     Region          176..329
                     /region_name="GGDEF"
                     /note="Diguanylate-cyclase (DGC) or GGDEF domain; cd01949"
                     /db_xref="CDD:143635"
     Site            order(212,255)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(217,220..221,225,229,251,253..256)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(247,275)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 msdfilarvs qtlaaeqsle tlvrqlleml eavtrmesty ltridtnaqr qqimfahnss
       61 emqipegfsv pwdeslckra ledqctfsnd vanrwhscia aqelgiatfl sipvrladgs
      121 lfgtlcatsr qqqpynlege qvmglfakli shyvekdtlv qqlqaanval elhsstdelt
      181 qlpnrralfk qlalrfasar aqqqqvslif idldgfkain drfghpcgds flvqvgkrlt
      241 avarredivg rlggdefliv gsaqqpaaqq ayvtslrqal cgvyflgeqr idyegasfgv
      301 vtcdpqsidv eaalrtadea myqdkksrrq enfihid