MULTISPECIES: voltage-gated ClC-type chloride channel ClcB

LOCUS       WP_004148305             431 aa            linear   BCT 21-APR-2023
            [Klebsiella].
ACCESSION   WP_004148305
VERSION     WP_004148305.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002437.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK01610
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..431
                     /gene="clcB"
     Protein         1..431
                     /product="voltage-gated ClC-type chloride channel ClcB"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0010447 - response to acidic pH [Evidence
                     IEA]"
                     /calculated_mol_wt=45483
     Region          13..430
                     /region_name="PRK01610"
                     /note="putative voltage-gated ClC-type chloride channel
                     ClcB; Provisional"
                     /db_xref="CDD:234963"
     Site            order(96..100,131..135,333..337)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238233"
     Site            order(97,99,133..134,333..335)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238233"
     Site            133
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238233"
     Site            order(177,186,201,208,381,384,392,400,407..408)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238233"
ORIGIN      
        1 mhrlhpypdv qvmfrrllia tligllaala valfrhamvv letlllsnds gslvnaaqsl
       61 pawrrlvtpa lggltagtll wlwqrrsvar phaatdymea letgdgcfdt paslvkslas
      121 llvvvtgsai gregamilla alaaslfarr ftpqsewklw vacgaaagma sayhaplags
      181 lfiaeilfgt lmlaslgpvv isavialllt qflnggaapl yhvvlqqnls alhyglmlat
      241 gllaglcgpl fiwlmdyshr gfvklklapp wqlalggliv gglslitpav wgngysvvqs
      301 ylllppsgal lvgvfickll avlassgsga pggvftptlf vglamgmlfa cfsrlwlpgs
      361 eemaimmglt gmaaflaatt hapimstlmi cemtgqytll pgllitcvvs svlsrtlrrd
      421 siyrhhvaeh v