MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004147923             404 aa            linear   BCT 22-JUL-2024
ACCESSION   WP_004147923
VERSION     WP_004147923.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..404
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=41841
     Region          15..388
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(25..26,29..30,33,65,115..116,118..119,122,142,
                     145..146,149,222,225..226,229..231,234,261,265,320..321,
                     325,329,344,347..348,351..352,355)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mtptslstrd agwiifilal gagfsvasiy yaqpllplmg anlhltvegm glvptltqag
       61 yalgilfllp lgdrhdrrrl ilvksallal llllcsltgq lssllvvsll igmaatmaqd
      121 ivpaaailap agkqgkmvgt vmtglllgil lsrtvsgvvg avfgwrvmyq aaavsvalig
      181 lvmwrvlprf avhstlsypq lmasmahlwq rypalrraal aqgalsiafs afwstlavml
      241 sehyhmgsav aggfgiagaa galaaplagg ladkfgagkv tqmgaalvtl sfalmfvlpl
      301 lpvhaqlali alsaigfdlg lqsslvahqn lvyglepqar grlnallftv vfigmslgsv
      361 lgsklyvlag wngvvtlavi tgalalairl lenarilaae rsas