MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004146734             397 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004146734
VERSION     WP_004146734.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024320
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..397
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=42231
     Region          15..387
                     /region_name="MFS_MJ1317_like"
                     /note="MJ1317 and similar transporters of the Major
                     Facilitator Superfamily; cd17370"
                     /db_xref="CDD:340928"
     Site            order(25..26,29..30,33,66,117..118,120..122,125,145,
                     148..149,152,225,228..229,232..234,237,264,268,317..318,
                     322,326,342,345..346,349..350,353)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340928"
ORIGIN      
        1 mvprfatlgr ipkgvwvlgg vsllmdvsse mihsllplfm attlgasvii iglieglaea
       61 talilkvfsg aisdyvgkrk glallgyglg alskplfaia ptagvvfsar midrvgkgir
      121 gaprdalvad vtppeirgaa yglrqaldtv gaflgpllav llmfiwandf haifwvavip
      181 avlsilllgf glqepksaia hkrsnplkre nlkklsaayw wvvaigsift larfseaflv
      241 lraqqmeipl ytiplvmvam nlvysltayp fgklsdsmsh skllqwgllv liladivlal
      301 sshwstllig valwgihmgm tqgllaamva htappelrgt afgmfnlmsg lalllastga
      361 gvlwetfgaa stfyagaiic vvtligmrvm psayrqd