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MULTISPECIES: bifunctional L-1,2-propanediol dehydrogenase/glycerol


LOCUS       WP_004146274             367 aa            linear   BCT 20-JAN-2025
            dehydrogenase [Gammaproteobacteria].
ACCESSION   WP_004146274
VERSION     WP_004146274.1
KEYWORDS    RefSeq.
SOURCE      Gammaproteobacteria
  ORGANISM  Gammaproteobacteria
            Bacteria; Pseudomonadati; Pseudomonadota.
REFERENCE   1  (residues 1 to 367)
  AUTHORS   Gonzalez,R., Murarka,A., Dharmadi,Y. and Yazdani,S.S.
  TITLE     A new model for the anaerobic fermentation of glycerol in enteric
            bacteria: trunk and auxiliary pathways in Escherichia coli
  JOURNAL   Metab Eng 10 (5), 234-245 (2008)
   PUBMED   18632294
REFERENCE   2  (residues 1 to 367)
  AUTHORS   Subedi,K.P., Kim,I., Kim,J., Min,B. and Park,C.
  TITLE     Role of GldA in dihydroxyacetone and methylglyoxal metabolism of
            Escherichia coli K12
  JOURNAL   FEMS Microbiol Lett 279 (2), 180-187 (2008)
   PUBMED   18179582
REFERENCE   3  (residues 1 to 367)
  AUTHORS   Truniger,V. and Boos,W.
  TITLE     Mapping and cloning of gldA, the structural gene of the Escherichia
            coli glycerol dehydrogenase
  JOURNAL   J Bacteriol 176 (6), 1796-1800 (1994)
   PUBMED   8132480
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF047954.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Gammaproteobacteria"
                     /db_xref="taxon:1236"
     gene            1..367
                     /gene="gldA"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008888 - glycerol dehydrogenase [NAD+]
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
     Protein         1..367
                     /product="bifunctional L-1,2-propanediol
                     dehydrogenase/glycerol dehydrogenase"
                     /EC_number="1.1.1.6"
                     /EC_number="1.1.1.75"
                     /GO_function="GO:0008888 - glycerol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0019147 - (R)-aminopropanol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019588 - anaerobic glycerol catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0051596 - methylglyoxal catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=38587
     Region          1..366
                     /region_name="gldA"
                     /note="glycerol dehydrogenase; Provisional; PRK09423"
                     /db_xref="CDD:181843"
     Site            order(9..11,13..14,205,208,231..232,235)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341449"
     Site            order(37,93..95,98,101,116..117,119,138..139,156,164,171,
                     175,254,258,271)
                     /site_type="active"
                     /db_xref="CDD:341449"
     Site            order(171,254,271)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:341449"
ORIGIN      
        1 mdriiqspgk yiqgagaikr lgdylkplae rwlvvgdkfv lgfaeemlrk sladaglaae
       61 iapfggecsh neinrlrdia gnakctavlg igggktldta kalahfmnvp vaiaptiast
      121 dapcsalsvi ytdegefdsy lmlprnpnmv ivdtqivaga parllaagig dalatwfear
      181 acsrsgattm aggkctqaal alaelcyntl leegekamla aeqhvvtpal ervveantyl
      241 sgvgfesggl aaahaihngm taipdahhyy hgekvafgtl tqlvlenapv deietvaalc
      301 hsvglpitla qldikgdipt kmrlvaeaac aegetihnmp ggvdsdqvya allvadqygq
      361 rflqewe