(2E,6E)-farnesyl-diphosphate-specific

LOCUS       WP_004145863             258 aa            linear   BCT 17-MAY-2022
            ditrans,polycis-undecaprenyl-diphosphate synthase [Klebsiella
            pneumoniae].
ACCESSION   WP_004145863
VERSION     WP_004145863.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 258)
  AUTHORS   Chang,S.Y., Ko,T.P., Chen,A.P., Wang,A.H. and Liang,P.H.
  TITLE     Substrate binding mode and reaction mechanism of undecaprenyl
            pyrophosphate synthase deduced from crystallographic studies
  JOURNAL   Protein Sci 13 (4), 971-978 (2004)
   PUBMED   15044730
REFERENCE   2  (residues 1 to 258)
  AUTHORS   Chang,S.Y., Ko,T.P., Liang,P.H. and Wang,A.H.
  TITLE     Catalytic mechanism revealed by the crystal structure of
            undecaprenyl pyrophosphate synthase in complex with sulfate,
            magnesium, and triton
  JOURNAL   J Biol Chem 278 (31), 29298-29307 (2003)
   PUBMED   12756244
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007596.1
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK10240
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..258
                     /gene="ispU"
                     /gene_synonym="uppS"
     Protein         1..258
                     /product="(2E,6E)-farnesyl-diphosphate-specific
                     ditrans,polycis-undecaprenyl-diphosphate synthase"
                     /GO_function="GO:0002094 - polyprenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008834 -
                     di-trans,poly-cis-decaprenylcistransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0043164 - Gram-negative-bacterium-type
                     cell wall biogenesis [Evidence IEA]"
                     /calculated_mol_wt=28822
     Region          30..258
                     /region_name="PRK10240"
                     /note="(2E,6E)-farnesyl-diphosphate-specific
                     ditrans,polycis-undecaprenyl-diphosphate synthase"
                     /db_xref="CDD:182326"
     Site            order(30..35,44,48,52,55,74,82,86,93..94,97,146,199,205,
                     207)
                     /site_type="active"
                     /db_xref="CDD:259850"
     Site            order(153..154,156..157,160..161,177..179,182,193,
                     204..208,211..213,215..219,221)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:259850"
ORIGIN      
        1 mdlkrvmlsa nqtvseispt hgcrhvaiim dgngrwakrq gkirafghka gaksvrravs
       61 faanngieal tlyafssenw nrpaqevsal melfvwalds evkslhrhnv rlriigdttr
      121 fnarlqerir kaealtannt gltlniaany ggrwditqgv rllakqvqdg tllpeqited
      181 mlsqqvcmhe lapvdlvirt ggehrisnfl iwqiayaely ftdvlwpdfa eqdfegalha
      241 fvnrerrfgg tepggsha