MULTISPECIES: LysR family transcriptional regulator [Klebsiella].

LOCUS       WP_004145376             290 aa            linear   BCT 19-FEB-2025
ACCESSION   WP_004145376
VERSION     WP_004145376.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Maddocks,S.E. and Oyston,P.C.F.
  TITLE     Structure and function of the LysR-type transcriptional regulator
            (LTTR) family proteins
  JOURNAL   Microbiology (Reading) 154 (Pt 12), 3609-3623 (2008)
   PUBMED   19047729
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Felder,C.B., Graul,R.C., Lee,A.Y., Merkle,H.P. and Sadee,W.
  TITLE     The Venus flytrap of periplasmic binding proteins: an ancient
            protein module present in multiple drug receptors
  JOURNAL   AAPS PharmSci 1 (2), E2 (1999)
   PUBMED   11741199
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Schell,M.A.
  TITLE     Molecular biology of the LysR family of transcriptional regulators
  JOURNAL   Annu Rev Microbiol 47, 597-626 (1993)
   PUBMED   8257110
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10444091
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..290
                     /product="LysR family transcriptional regulator"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription
                     factor activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /calculated_mol_wt=32423
     Region          3..62
                     /region_name="HTH_1"
                     /note="Bacterial regulatory helix-turn-helix protein, lysR
                     family; pfam00126"
                     /db_xref="CDD:459683"
     Region          92..290
                     /region_name="PBP2_BudR"
                     /note="The C-terminal substrate binding domain of
                     LysR-type transcrptional regulator BudR, which is
                     responsible for activation of the expression of the
                     butanediol operon genes; contains the type 2 periplasmic
                     binding fold; cd08451"
                     /db_xref="CDD:176142"
     Site            order(97,105,108..109,111..112,115,123,125,127,172,
                     206..207,226..227,233..234,236..237,255)
                     /site_type="other"
                     /note="putative dimerization interface [polypeptide
                     binding]"
                     /db_xref="CDD:176142"
     Site            order(98,148,196..197,204)
                     /site_type="other"
                     /note="putative substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:176142"
ORIGIN      
        1 melrylryfv avartrhftq aakelgisqp plsqqiqrle revgtplfrr ltrgveltea
       61 gesfyedarq ilamsdaale kakgiargmn gslslgitss dafhpqiftl lhrfqldhpg
      121 vtlhqmednm anlmtalsea eldiafvrlp cesskafnlr iideepmvia lprdnplatq
      181 ptlaleqlrd vapilfprev apglyelvyn sclragidme rawqssqiss slsmvnagfg
      241 falvpqsmtc iqqpnvsyhp lsgaplktdi aiawrrfers rtvkrflamf