MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004144660             454 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004144660
VERSION     WP_004144660.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024624
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..454
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48730
     Region          17..388
                     /region_name="MFS_YajR_like"
                     /note="Escherichia coli inner membrane transport protein
                     YajR and similar multidrug-efflux transporters of the
                     Major Facilitator Superfamily; cd17472"
                     /db_xref="CDD:341025"
     Site            order(24..25,28..29,32,65,115..116,118..120,123,145,
                     148..149,152,221,224..225,228..230,233,260,264,308..309,
                     313,317,340,343..344,347..348,351)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341025"
ORIGIN      
        1 mndnkmtpge lratwglgtv fslrmlgmfm vlpvlttygm alqgaseali glaigiygla
       61 qavfqipfgl lsdrigrkpl ivggllifvl gsviaaltds iwgiilgral qgsgaiaaav
      121 mallsdltre qnrtkamafi gvsfgvtfai amvlgpivth qlglhalfwm iailatvgil
      181 ltlwvvpnsh nhvlnresgm vkgcfskvla eprllklnfg imclhimlms tfvalpgqle
      241 aagfpaaehw kiylvtmvis fisvvpfiiy aevkrkmkrv fllcvailli aeivlwgagg
      301 yfwelvagvq lfflafnlle allpsliske spagykgtam gvystsqflg vaiggalggw
      361 vdgffdsqtv fllgallaml wllvastmse ppyvsslrve vpdgvvvdsa lqarllsasg
      421 vhqalvvpee rsvyikidsk vtnrfeieql ikgv