MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004143698             468 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004143698
VERSION     WP_004143698.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 468)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 468)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 468)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..468
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=51682
     Region          39..455
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(49..50,53..54,57,97,147..148,150..152,155,175,
                     178..179,182,291,294..295,298..300,303,330,334,383..384,
                     388,392,408,411..412,415..416,419)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 msttqvlget pyaspgqpha sltgridalp asfglwsfit llslggffel ydlfqtgyis
       61 agllaegifh tgqagifgia dqaafasatf mglfigasll apladklgrr ltfmvalawy
      121 glfsllmatq ssaegviffr flvgiglgie lvtidtylse wvpthlrnka fafaffiqfl
      181 svpavalmsw mlvpttlfgl sgwrwviifg alfslaiwfi rkklpesarw leskgrhdda
      241 htvmcemear cgltpspkha haaqsvvkrg tfreiwapqy rqrtlmlmvm nffqaigffg
      301 fgnwlpalls gqgasithsl lyaffitlay plgclfctrf vhrfenkwqi vlsalmtvif
      361 gtlfalqnsp illvicgfmi twsnawltis yhayqaevfp thiraravgf cysfsrlsta
      421 vtsiligiil qyagtpgvis fivvsmlmvm lsvgifgprt rgirleni