MULTISPECIES: sugar porter family MFS transporter [Klebsiella].

LOCUS       WP_004143440             481 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004143440
VERSION     WP_004143440.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024203
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..481
                     /product="sugar porter family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=52634
     Region          17..448
                     /region_name="MFS_XylE_like"
                     /note="D-xylose-proton symporter and similar transporters
                     of the Major Facilitator Superfamily; cd17359"
                     /db_xref="CDD:340917"
     Site            order(29,147,150,154,273..274,278..279,282..283,372,
                     376..377,381,404..405,408)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340917"
ORIGIN      
        1 msfitnlnqq qrkrlhqitl vatfggllfg ydtgvingaf sslkqymalt ptteglvmsv
       61 llvgaalgsv fggkfadyfg rrkyllflsf vfligallsa aapdittlli arallgyavg
      121 gasvtaptfi sevaptemrg kltglnevai vigqlaafai naiigiiwgh lpdvwrymll
      181 vqaipaiclf vgmwrapesp rwlisknrhd ealhilkqir paeraqkeyd distlikiea
      241 gnkysaqstf ativktpwil killvgitwa alqqttgvnv imyygteils aagfsertsl
      301 icnvlngvfs vggmligvlf lvdrfkrkti iiygfaimat lhliiaavdy tlvgdlkata
      361 iwllgalfvg vmqgsmgfit wvvlaelfpl kfrglsmgis vffmwimnav vsylfpllqa
      421 klglgpvffi faainylail fvvfalpets nksleqleae lsanhedkks trltrevgyd
      481 r