Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS WP_004143132 407 aa linear BCT 26-JUN-2024 pneumoniae]. ACCESSION WP_004143132 VERSION WP_004143132.1 KEYWORDS RefSeq. SOURCE Klebsiella pneumoniae ORGANISM Klebsiella pneumoniae Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella; Klebsiella pneumoniae complex. REFERENCE 1 (residues 1 to 407) AUTHORS Schiefner,A., Gerber,K., Seitz,S., Welte,W., Diederichs,K. and Boos,W. TITLE The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli JOURNAL J Biol Chem 280 (32), 29073-29079 (2005) PUBMED 15929984 REFERENCE 2 (residues 1 to 407) AUTHORS Tanaka,Y., Itoh,F., Kimata,K. and Aiba,H. TITLE Membrane localization itself but not binding to IICB is directly responsible for the inactivation of the global repressor Mlc in Escherichia coli JOURNAL Mol Microbiol 53 (3), 941-951 (2004) PUBMED 15255904 REFERENCE 3 (residues 1 to 407) AUTHORS Seitz,S., Lee,S.J., Pennetier,C., Boos,W. and Plumbridge,J. TITLE Analysis of the interaction between the global regulator Mlc and EIIBGlc of the glucose-specific phosphotransferase system in Escherichia coli JOURNAL J Biol Chem 278 (12), 10744-10751 (2003) PUBMED 12529317 REFERENCE 4 (residues 1 to 407) AUTHORS Plumbridge,J. TITLE DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli JOURNAL Nucleic Acids Res 29 (2), 506-514 (2001) PUBMED 11139621 REFERENCE 5 (residues 1 to 407) AUTHORS Decker,K., Plumbridge,J. and Boos,W. TITLE Negative transcriptional regulation of a positive regulator: the expression of malT, encoding the transcriptional activator of the maltose regulon of Escherichia coli, is negatively controlled by Mlc JOURNAL Mol Microbiol 27 (2), 381-390 (1998) PUBMED 9484893 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: BlastRule Evidence Accession :: NBR008037 Evidence Source :: NCBI ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..407 /organism="Klebsiella pneumoniae" /db_xref="taxon:573" gene 1..407 /gene="mlc" /gene_synonym="dgsA" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" Protein 1..407 /product="sugar metabolism global transcriptional regulator Mlc" /calculated_mol_wt=44536 Region 21..61 /region_name="HTH_CRP" /note="helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; cl46859" /db_xref="CDD:481199" Region 85..407 /region_name="ASKHA_ATPase_ROK_Mlc" /note="ATPase-like domain of protein Mlc and similar proteins; cd24074" /db_xref="CDD:466924" ORIGIN 1 mvvadsqpgh idqikqtnag avyrlidqlg pvsridlsrf aqlapasitk ivremleahl 61 vqeteiqepg srgrpavglm veteawhyla vrisrgeihl slrdlssqlv vedqlelalt 121 dstpfltrvi dhidrffirh qkklerltsi amtmpgiidt engiihrmpf yedvkdvplg 181 ealanhtgvp vyiqhdisaw tmaeslfgas rgardviqvv idhnvgagvi tdgrllhags 241 sslveightq vdpygkrcyc gnhgcletia svesvlelaq mrmaqsmssl lhqrplsvew 301 lcqaalqgdl lardiisgvg nhvgrilaim vnlfnpqkil igspfnlaae ilfpaissci 361 rqqslpaysr hitvestqfs nrgtmagaal vkdalyngsl lirllqg