orotidine-5'-phosphate decarboxylase [Klebsiella pneumoniae].

LOCUS       WP_004140290             228 aa            linear   BCT 10-DEC-2019
ACCESSION   WP_004140290
VERSION     WP_004140290.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 228)
  AUTHORS   Lee,T.S., Chong,L.T., Chodera,J.D. and Kollman,P.A.
  TITLE     An alternative explanation for the catalytic proficiency of
            orotidine 5'-phosphate decarboxylase
  JOURNAL   J. Am. Chem. Soc. 123 (51), 12837-12848 (2001)
   PUBMED   11749542
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001273.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00230
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..228
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..228
                     /gene="pyrF"
     Protein         1..228
                     /product="orotidine-5'-phosphate decarboxylase"
                     /EC_number="4.1.1.23"
                     /GO_function="GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=24533
     Region          2..225
                     /region_name="PRK00230"
                     /note="orotidine-5'-phosphate decarboxylase"
                     /db_xref="CDD:234695"
     Site            order(3,5,27,29,54,56,113..114,172,204..205)
                     /site_type="active"
                     /db_xref="CDD:240076"
     Site            order(29,31..32,55..56,58..59,62..63,66..67,82..84,95,113,
                     133,205)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:240076"
ORIGIN      
        1 mvaldydnrd kalafvdrid prdcrlkvgk emftllgpqf vrdlhqrgfe vfldlkfhdi
       61 pnttaravaa aaelgvwmvn vhasggarmm taareallpf gkdaplliav tvltsmessd
      121 lqdlgitlsp adyaaklaal tqrcgldgvv csaqeavrfk helgqafklv tpgirpqgsd
      181 agdqrrimtp eqaqeagvdy mvigrpvtqs adpaatlrai ndslrkga