phenylalanine--tRNA ligase subunit alpha [Listeria monocytogenes].

LOCUS       WP_003736387             350 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_003736387
VERSION     WP_003736387.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 350)
  AUTHORS   Abibi,A., Ferguson,A.D., Fleming,P.R., Gao,N., Hajec,L.I., Hu,J.,
            Laganas,V.A., McKinney,D.C., McLeod,S.M., Prince,D.B., Shapiro,A.B.
            and Buurman,E.T.
  TITLE     The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA
            synthetase druggability
  JOURNAL   J Biol Chem 289 (31), 21651-21662 (2014)
   PUBMED   24936059
REFERENCE   2  (residues 1 to 350)
  AUTHORS   Mermershtain,I., Finarov,I., Klipcan,L., Kessler,N., Rozenberg,H.
            and Safro,M.G.
  TITLE     Idiosyncrasy and identity in the prokaryotic Phe-system: crystal
            structure of E. coli phenylalanyl-tRNA synthetase complexed with
            phenylalanine and AMP
  JOURNAL   Protein Sci 20 (1), 160-167 (2011)
   PUBMED   21082706
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00468.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..350
                     /gene="pheS"
     Protein         1..350
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=39142
     Region          2..342
                     /region_name="PheS"
                     /note="Phenylalanyl-tRNA synthetase alpha subunit
                     [Translation, ribosomal structure and biogenesis];
                     COG0016"
                     /db_xref="CDD:439787"
ORIGIN      
        1 mleqlqtlks eaetqineas dlktlndlrv kylgkkgpmt eimkqmgkls aeerpkmgsl
       61 anevrtalte aisskqqile teaineklks etidvtlpgt apsigtkhll tqvieemedm
      121 figmgyeiae gpeveldyyn fealnlpkdh pardmqdsfy itentllrtq tspvqartme
      181 khdfskgpik vicpgkvyrr dnddathshq ftqieglvvg enitfadlkg tltvlaktmf
      241 geereirlrp sffpftepsv emdiscfkcg gkgcrvckgt gwieilgsgm vhpnvlemsg
      301 idstrysgfa fglgpervam lkyavddirh lytndlrftk qfqstetgei