cholic acid efflux MFS transporter MdrT [Listeria monocytogenes].

LOCUS       WP_003733258             493 aa            linear   BCT 11-APR-2024
ACCESSION   WP_003733258
VERSION     WP_003733258.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Schwartz,K.T., Carleton,J.D., Quillin,S.J., Rollins,S.D.,
            Portnoy,D.A. and Leber,J.H.
  TITLE     Hyperinduction of host beta interferon by a Listeria monocytogenes
            strain naturally overexpressing the multidrug efflux pump MdrT
  JOURNAL   Infect Immun 80 (4), 1537-1545 (2012)
   PUBMED   22290148
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Quillin,S.J., Schwartz,K.T. and Leber,J.H.
  TITLE     The novel Listeria monocytogenes bile sensor BrtA controls
            expression of the cholic acid efflux pump MdrT
  JOURNAL   Mol Microbiol 81 (1), 129-142 (2011)
   PUBMED   21542862
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR014711
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..493
                     /gene="mdrT"
                     /gene_synonym="ycnB"
     Protein         1..493
                     /product="cholic acid efflux MFS transporter MdrT"
                     /calculated_mol_wt=52793
     Region          26..480
                     /region_name="MFS_LmrB_MDR_like"
                     /note="Bacillus subtilis lincomycin resistance protein
                     (LmrB) and similar multidrug resistance (MDR) transporters
                     of the Major Facilitator Superfamily; cd17503"
                     /db_xref="CDD:341046"
     Site            order(33..34,37..38,41,73,123..124,126..128,131,151,
                     154..155,158,282,285..286,289..291,294,322,326,378..379,
                     383,387,403,406..407,410..411,414)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341046"
ORIGIN      
        1 mnstaverpv dvngksysrs llvvtmiiga fvailnqtll atalpmimdd lhitaatgqw
       61 lttaflltng imipitalli ekissktlfi tamtvftigt iiasvagsfp illtgrivqa
      121 agagimmpll qtifllifpr ekrgaamglm glviafapai gptlsgwivd sydwrvlfli
      181 lipiavidii laffgmkkvv kltdtkidfl sivmssigfg allygfssag ndgwgdttvi
      241 tmlivgvvvi alfvwrqlvi dnpmlelhvf kypvfslsvi lgsivtmami gaeivlplyi
      301 qtirgesalq sgllllpgai imgimspitg iifdkigakw ltitgvtilt igtipfmflt
      361 mdtplwyivv fyavrffgis mammpvstag mnalpnhlin hgsavnntir qiagsigtav
      421 litvltnvtk dnmpgkalma tdpasfaqka qdasldgmra afmvaaifaa igmilslflk
      481 tkkqepivke ytk