carbamoyl-phosphate synthase large subunit [Listeria

LOCUS       WP_003733084            1070 aa            linear   BCT 07-MAY-2024
            monocytogenes].
ACCESSION   WP_003733084
VERSION     WP_003733084.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 1070)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 1070)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J Biol Chem 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 1070)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 1070)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
REFERENCE   5  (residues 1 to 1070)
  AUTHORS   Trotta,P.P., Pinkus,L.M., Haschemeyer,R.H. and Meister,A.
  TITLE     Reversible dissociation of the monomer of glutamine-dependent
            carbamyl phosphate synthetase into catalytically active heavy and
            light subunits
  JOURNAL   J Biol Chem 249 (2), 492-499 (1974)
   PUBMED   4358555
REFERENCE   6  (residues 1 to 1070)
  AUTHORS   Khedouri,E., Anderson,P.M. and Meister,A.
  TITLE     Selective inactivation of the glutamine binding site of Escherichia
            coli carbamyl phosphate synthetase by
            2-amino-4-oxo-5-chloropentanoic acid
  JOURNAL   Biochemistry 5 (11), 3552-3557 (1966)
   PUBMED   5339592
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003671.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05294
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..1070
                     /gene="carB"
     Protein         1..1070
                     /product="carbamoyl-phosphate synthase large subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence
                     IEA]"
                     /calculated_mol_wt=117645
     Region          1..1054
                     /region_name="carB"
                     /note="carbamoyl-phosphate synthase large subunit;
                     PRK05294"
                     /db_xref="CDD:235393"
ORIGIN      
        1 mpkrddikti lvigsgpivi gqaaefdyag tqaclslkee gyrvvlvnsn patimtdaem
       61 adkvyiepit ldfvsriirk erpdailptl ggqtglnmam elsaagilde cnvevlgtdl
      121 taikkaedre afrdlmnelg epvpesdiih nldeayafve rigypvivrp aytlggsggg
      181 ichneqelie tvtsglklsp vtqclleksi agfkeveyev mrdannnamv vcnmenidpv
      241 gihtgdsivv apsqtlsdre yqllrdvslk iiraleiegg cnvqlaldpd synyyvievn
      301 prvsrssala skatgypiak laakiavglt ldevrnpvtg ttfahfeptl dyvvakiprf
      361 afdkfeqadr rlgtqmkatg evmaigrswe eallkavrsl eigadhllle eaenadeatl
      421 erkicfpedd rlfflaaalr rgqtieqlhe ktkidlffly klsktielen rikenpqnqe
      481 ilaeakqagf sdaflatcwn vdeqaiydlr kaqnlfpvyk mvdtcaaefe sttpyfysty
      541 eeenestrsa kesvivlgsg pirigqgvef dyatvhsvwa iqqagyeaii innnpetvst
      601 dfsisdklyf epltledvmh vieieqplgv vvqfggqtai nladglakrg vkilgtsled
      661 tdraenrdaf ekaleilqip qpagktatsv eeaitvatdi gypvlvrpsy vlggrameiv
      721 eseealkhym tnavkvnpkh pvlvdryvsg qevevdaisd gvnvlipgim ehieragvhs
      781 gdsiavypaq rlsiqvknti vdyttrlatg lniigmlniq yvvdgeevfv ievnprssrt
      841 apflskitei pmanvatrvi lgenlidlgy tpglapekqe ifvkvpvfsf aklrsvdtsl
      901 gpemkstgev mgkdvtleka lykgfvasgt tmhdygtvll tvadrdkeea velakrfnri
      961 gftimatkgt astleeasip vsqvkkigen qetlidyirn gqvtlvvntl ttgkrperdg
     1021 fqirresven gipvctsldt aeailrvles rsfelesmna sevkqpksrv