MULTISPECIES: serine hydroxymethyltransferase [Listeria].

LOCUS       WP_003732521             413 aa            linear   BCT 29-MAR-2023
ACCESSION   WP_003732521
VERSION     WP_003732521.1
KEYWORDS    RefSeq.
SOURCE      Listeria
  ORGANISM  Listeria
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae.
REFERENCE   1  (residues 1 to 413)
  AUTHORS   Appaji Rao,N., Ambili,M., Jala,V.R., Subramanya,H.S. and
            Savithri,H.S.
  TITLE     Structure-function relationship in serine hydroxymethyltransferase
  JOURNAL   Biochim Biophys Acta 1647 (1-2), 24-29 (2003)
   PUBMED   12686103
REFERENCE   2  (residues 1 to 413)
  AUTHORS   Stover,P. and Schirch,V.
  TITLE     Serine hydroxymethyltransferase catalyzes the hydrolysis of
            5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate
  JOURNAL   J Biol Chem 265 (24), 14227-14233 (1990)
   PUBMED   2201683
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10011056
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Listeria"
                     /db_xref="taxon:1637"
     gene            1..413
                     /gene="glyA"
     Protein         1..413
                     /product="serine hydroxymethyltransferase"
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine
                     hydroxymethyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process
                     from serine [Evidence IEA]"
                     /calculated_mol_wt=44992
     Region          1..413
                     /region_name="glyA"
                     /note="serine hydroxymethyltransferase; Reviewed;
                     PRK00011"
                     /db_xref="CDD:234571"
     Site            order(8,10,17..18,27,32,50,68..69,77,92,99,134..135,259,
                     277)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99733"
     Site            order(31,51,61,94..95,122,172,197,200,225..226,232,357)
                     /site_type="other"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99733"
     Site            order(31,122,226,357)
                     /site_type="active"
                     /db_xref="CDD:99733"
     Site            order(53,60,117,121,123,251,341)
                     /site_type="other"
                     /note="folate binding site [chemical binding]"
                     /db_xref="CDD:99733"
ORIGIN      
        1 mvylqkqdke vfdaiklelg rqranielia senfvseqvm eamgsvltnk yaegypgkry
       61 yggcefvdiv edlardrakk lfgaeyanvq phsgaqanma vyhtvlepgd tvlgmnlshg
      121 ghlthgspvn fsgvlynfve ygvredtkei dydivreaal khkpkmivag asayprkidf
      181 akfreiadev gaylmvdmah iaglvaaglh qnpvpyadft tttthktlrg prggmilaka
      241 eweqklnksi fpgiqggplm hviaakavaf gealqpeftt yceqiirnsk klaetlqand
      301 vavltggsdn hlllidlkpl gltgkaaekv ldevgitvnk ntipfetesp fvtsgirvgv
      361 aavttrgfde vaiekvgvli sevlhnlene evladvkarv atltneyply psl