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LOCUS WP_003732050 375 aa linear BCT 31-DEC-2024 ACCESSION WP_003732050 VERSION WP_003732050.1 KEYWORDS RefSeq. SOURCE Listeria monocytogenes ORGANISM Listeria monocytogenes Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria. REFERENCE 1 (residues 1 to 375) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 375) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 375) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 375) AUTHORS D'Argenio,D.A. and Miller,S.I. TITLE Cyclic di-GMP as a bacterial second messenger JOURNAL Microbiology (Reading) 150 (Pt 8), 2497-2502 (2004) PUBMED 15289546 REFERENCE 5 (residues 1 to 375) AUTHORS Jenal,U. TITLE Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria? JOURNAL Curr Opin Microbiol 7 (2), 185-191 (2004) PUBMED 15063857 REFERENCE 6 (residues 1 to 375) AUTHORS Pei,J. and Grishin,N.V. TITLE GGDEF domain is homologous to adenylyl cyclase JOURNAL Proteins 42 (2), 210-216 (2001) PUBMED 11119645 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10005578 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..375 /organism="Listeria monocytogenes" /db_xref="taxon:1639" Protein 1..375 /product="GGDEF domain-containing protein" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /calculated_mol_wt=42916 Region 118..370 /region_name="GGDEF" /note="GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms]; COG2199" /db_xref="CDD:441801" ORIGIN 1 mfelvnsyid slalflailf iqgmsfrkir qyrpnwfqng srrlflsill gvyyglagiy 61 fiyegayenn pviytnmril ilmvtsvfgg riplifaylv mlfgrisfdi aspttsryvi 121 lmtlifaacl lvtfwkkqrf srfvaliiln fpailyyfvn nfdegrilrg feiieyfllf 181 fvtallvfya cnyidksnlv iqnltetamt dsltnlpnmr fftqqfgwif tksqkrkksl 241 slfiididhf keindfhghq agntvlaqfs silknrtfpp rtmfarigge efavllqnvg 301 teqaaliadf freeverakf pynpasgkvt vsigvasass nfstteslfe aadqalyqak 361 qngrnqiavh qgele