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penicillin-binding protein [Listeria monocytogenes].


LOCUS       WP_003731976             751 aa            linear   BCT 29-MAR-2023
ACCESSION   WP_003731976
VERSION     WP_003731976.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Shalaby,M.W., Dokla,E.M.E., Serya,R.A.T. and Abouzid,K.A.M.
  TITLE     Penicillin binding protein 2a: An overview and a medicinal
            chemistry perspective
  JOURNAL   Eur J Med Chem 199, 112312 (2020)
   PUBMED   32442851
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Shaku,M., Ealand,C., Matlhabe,O., Lala,R. and Kana,B.D.
  TITLE     Peptidoglycan biosynthesis and remodeling revisited
  JOURNAL   Adv Appl Microbiol 112, 67-103 (2020)
   PUBMED   32762868
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11433624
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..751
                     /product="penicillin-binding protein"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=81768
     Region          1..590
                     /region_name="FtsI"
                     /note="Cell division protein FtsI, peptidoglycan
                     transpeptidase (Penicillin-binding protein 2) [Cell cycle
                     control, cell division, chromosome partitioning, Cell
                     wall/membrane/envelope biogenesis]; COG0768"
                     /db_xref="CDD:440531"
     Region          603..657
                     /region_name="PASTA_Pbp2x-like_1"
                     /note="PASTA domain of PBP2x-like proteins, first repeat.
                     Penicillin-binding proteins (PBPs) are the major targets
                     for beta-lactam antibiotics, like penicillins and
                     cephalosporins. Beta-lactam antibiotics specifically
                     inhibit transpeptidase activity by...; cd06576"
                     /db_xref="CDD:119327"
     Region          603..656
                     /region_name="PASTA domain"
                     /note="PASTA domain [structural motif]"
                     /db_xref="CDD:275384"
     Region          661..714
                     /region_name="PASTA_Pbp2x-like_2"
                     /note="PASTA domain of PBP2x-like proteins, second repeat.
                     Penicillin-binding proteins (PBPs) are the major targets
                     for beta-lactam antibiotics, like penicillins and
                     cephalosporins. Beta-lactam antibiotics specifically
                     inhibit transpeptidase activity by...; cd06575"
                     /db_xref="CDD:119326"
     Region          661..713
                     /region_name="PASTA domain"
                     /note="PASTA domain [structural motif]"
                     /db_xref="CDD:275384"
ORIGIN      
        1 mkrrignmrr galvlfifft ilfllvsgrf lylqitgean gvplaakask qhlkssvlea
       61 krgsildrkg evlaedtasy tvaavvsdkl skttknpmrv vdeektaril akyipmdesd
      121 ildklhekgk yqvefgaagk nistetkaki dkenlpgief trqserfypn gtfatqligf
      181 aqqeeeknat vlegkmgies ryndiltgkn gkidystdrm gyilpnsknk vteakdgkdi
      241 tltldkkiqt fledtmttvd akykpknmma vvadpktgei laisqrpsfn padrstitgn
      301 sssiwqdlpv eyayepgsvm kiislasaid tnaynaneyy qsgsykvgdi aihdhnngng
      361 wgsityregv erssnvafak llnkmgtdtf ktyldkfgfg kktgialpne tsgkilynyp
      421 iekvttvfgq gttvsmmqmi qaasaiasdg tmkepyvvss vkdpntgeet dtktkiagkp
      481 isaetakktr delknvisge hgtgklyaip gydvagktgt sqipdpktgk ymtgadnyif
      541 sflgmapadn pelviyvtmq qpqlsgsqtg geavsevfnp vmknslqymn ikpgdaekla
      601 sekvpvlagk kvdeakkivk dkglepivvg ngkkivqqlp qanaeimqgq kvilmtdgdm
      661 tapdmvtwsk ddalkvseit gipfefsgng yvksqsvsag svinsetkmk itlappeeis
      721 afnqnhdqdt aeknkkatdi qenagigdll n