MATE family efflux transporter [Listeria monocytogenes].

LOCUS       WP_003724070             456 aa            linear   BCT 21-MAR-2023
ACCESSION   WP_003724070
VERSION     WP_003724070.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11479710
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..456
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /calculated_mol_wt=49525
     Region          1..446
                     /region_name="PRK01766"
                     /note="multidrug efflux protein; Reviewed"
                     /db_xref="CDD:234981"
     Site            order(255,259,285,288,367,371,398,423,427)
                     /site_type="other"
                     /note="cation binding site [ion binding]"
                     /db_xref="CDD:240536"
ORIGIN      
        1 mqqtvtygak wkqfltiftp ivitqltlfs mtffdttmsg nysnqalagv aigssfwapv
       61 naafsgllma itpiiaqlig akkekqvknt vhnglyialf lafililinf lvvpmilthm
      121 pvtaevadia rhflngicig ipaffisail rsfidslglt rvtmlitlct vpfniflnyc
      181 fifgnfgfpe mggagsgyat gitywlvvlv sviliqtqtr lrkfgvfkgl talrfskike
      241 iigigvpngl tilfetsifs avtilmgafg tetiaahqsa nsvctllyaf plsvastlti
      301 lggyetgakr lkdakqyrhi gmaaailigc vngailfffr diiagfytnd palsnlimhf
      361 lvyailfqfa davlspvlga lrgykdvtvt sivafisywl iglpvgygls ftnlgpfgyw
      421 iglstglfva afilsirvrk teqklsfntk daeisn