PrsW family glutamic-type intramembrane protease [Listeria

LOCUS       WP_003723562             379 aa            linear   BCT 02-MAR-2025
            monocytogenes].
ACCESSION   WP_003723562
VERSION     WP_003723562.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Pei,J., Mitchell,D.A., Dixon,J.E. and Grishin,N.V.
  TITLE     Expansion of type II CAAX proteases reveals evolutionary origin of
            gamma-secretase subunit APH-1
  JOURNAL   J Mol Biol 410 (1), 18-26 (2011)
   PUBMED   21570408
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Ellermeier,C.D. and Losick,R.
  TITLE     Evidence for a novel protease governing regulated intramembrane
            proteolysis and resistance to antimicrobial peptides in Bacillus
            subtilis
  JOURNAL   Genes Dev 20 (14), 1911-1922 (2006)
   PUBMED   16816000
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF024760.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF13367.11
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..379
                     /product="PrsW family glutamic-type intramembrane
                     protease"
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=42230
     Region          4..>36
                     /region_name="GYF_2"
                     /note="GYF domain 2; pfam14237"
                     /db_xref="CDD:464112"
     Region          111..363
                     /region_name="PrsW"
                     /note="Membrane proteinase PrsW, cleaves anti-sigma factor
                     RsiW, M82 family [Signal transduction mechanisms];
                     COG2339"
                     /db_xref="CDD:441909"
ORIGIN      
        1 msewyfkkne qkvgpftnve mialyrkkei nnltlvqksp hpewvvfkqt elhqhalnhg
       61 nselkignlf savfkkhske egekvfiagt kyttpatsdi phtwphpwvf srvflvliit
      121 yflllactyl fdnsntipgl mvigsfavpf svllfffetn aprnisvfdv vkmffiggva
      181 alvatlviys iipvgklnyf nallvgfiee tgkmiivalf irslnskyil nglligaavg
      241 agfaafeslg yafnysvdaa flfkdihiag etmmnvifsr gwqsigghvv waaitgaalv
      301 iakgdqklgm hhiftgtfwk wfiipialhf vwdcpfnplp aiafkqivli vivwfvilrl
      361 iskglkqvsv isaaskatk