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RelA/SpoT family protein [Listeria monocytogenes].


LOCUS       WP_003723527             738 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_003723527
VERSION     WP_003723527.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 738)
  AUTHORS   Ahmad,S., Gordon,I.J., Tsang,K.K., Alexei,A.G., Sychantha,D.,
            Colautti,J., Trilesky,S.L., Kim,Y., Wang,B. and Whitney,J.C.
  TITLE     Identification of a broadly conserved family of enzymes that
            hydrolyze (p)ppApp
  JOURNAL   Proc Natl Acad Sci U S A 120 (14), e2213771120 (2023)
   PUBMED   36989297
REFERENCE   2  (residues 1 to 738)
  AUTHORS   Ronneau,S. and Hallez,R.
  TITLE     Make and break the alarmone: regulation of (p)ppGpp
            synthetase/hydrolase enzymes in bacteria
  JOURNAL   FEMS Microbiol Rev 43 (4), 389-400 (2019)
   PUBMED   30980074
REFERENCE   3  (residues 1 to 738)
  AUTHORS   Chipman,D.M. and Shaanan,B.
  TITLE     The ACT domain family
  JOURNAL   Curr Opin Struct Biol 11 (6), 694-700 (2001)
   PUBMED   11751050
REFERENCE   4  (residues 1 to 738)
  AUTHORS   Aravind,L. and Koonin,E.V.
  TITLE     DNA polymerase beta-like nucleotidyltransferase superfamily:
            identification of three new families, classification and
            evolutionary history
  JOURNAL   Nucleic Acids Res 27 (7), 1609-1618 (1999)
   PUBMED   10075991
REFERENCE   5  (residues 1 to 738)
  AUTHORS   Aravind,L. and Koonin,E.V.
  TITLE     The HD domain defines a new superfamily of metal-dependent
            phosphohydrolases
  JOURNAL   Trends Biochem Sci 23 (12), 469-472 (1998)
   PUBMED   9868367
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11416884
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..738
                     /product="RelA/SpoT family protein"
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0008728 - GTP diphosphokinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008893 -
                     guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /calculated_mol_wt=84583
     Region          3..738
                     /region_name="SpoT"
                     /note="(p)ppGpp synthase/hydrolase, HD superfamily [Signal
                     transduction mechanisms, Transcription]; COG0317"
                     /db_xref="CDD:440086"
ORIGIN      
        1 makeqnltae qvidmashym nqehlalvkk ayefardshk eqfrksgepy iihpiqvagi
       61 lvelkmdpst vasgflhdvv edtpvtladl eevfgsevam lvdgvtklgk ikyksheeqq
      121 aenhrkmfia maqdirvili kladrlhnmr tlkhlpvekq rrianetlei faplahrlgi
      181 srvkweledt alrylnpqqy yrivhlmkqk rdarerylhd vidgvnenld elniqadisg
      241 rpkhiysiyr kmseqnkqfn eiydllavri vvssikdcya vlgiihtrwk pmpgrfkdyi
      301 ampksnmyqs ihttvigpqg eplevqirth emhqiaeygv aahwaykegk vvnsktsfdn
      361 kltwfreile yqnesdnaee fmeslkldlf sdvvyvftpk gdvyelpngs vpldfayrvh
      421 teignktiga kingkivtld yklktgdiid iltskhsygp srdwlklvqt sqarnkikqf
      481 fkrqakeenv ekgrdlveke irqlgfepkk imaaenlrkl adklnfshed dlfaavgyng
      541 italqvanrl teklrkerel eaeteklltq senkpsnsda nneklkikhn agvvvqgvgn
      601 llirlsrccn pvpgddivgy itkgrgisih rqdcpnvqai eperlievdw edadsqaknd
      661 ynvdieiygy nrngllndil qvinsltsni ngvnakvdnn kmatlvvtlq ihninhlqrv
      721 vdkikqipdv ytvrrlmn