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thiamine diphosphokinase [Listeria monocytogenes].


LOCUS       WP_003723061             214 aa            linear   BCT 11-APR-2024
ACCESSION   WP_003723061
VERSION     WP_003723061.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 214)
  AUTHORS   Melnick,J., Lis,E., Park,J.H., Kinsland,C., Mori,H., Baba,T.,
            Perkins,J., Schyns,G., Vassieva,O., Osterman,A. and Begley,T.P.
  TITLE     Identification of the two missing bacterial genes involved in
            thiamine salvage: thiamine pyrophosphokinase and thiamine kinase
  JOURNAL   J. Bacteriol. 186 (11), 3660-3662 (2004)
   PUBMED   15150256
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01378.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..214
                     /product="thiamine diphosphokinase"
                     /EC_number="2.7.6.2"
                     /GO_function="GO:0004788 - thiamine diphosphokinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006772 - thiamine metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=23585
     Region          4..212
                     /region_name="TPK"
                     /note="Thiamine pyrophosphokinase; cd07995"
                     /db_xref="CDD:153431"
     Site            order(8..10,31..33,51,53..54,77..82,102,104..106,109,113,
                     175,177,189,190..191)
                     /site_type="active"
                     /db_xref="CDD:153431"
     Site            order(33,37,40,77..79,83,103,105..112,114..115,136,138,
                     156,158,160,162..163,188,190,210)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:153431"
     Site            order(51,77..80,175,177,189,190..191)
                     /site_type="other"
                     /note="thiamine binding site [chemical binding]"
                     /db_xref="CDD:153431"
ORIGIN      
        1 mktinimvgg paseipdlaq ytsgeiswig vdrgakrlld rgiiptiamg dfdslskeel
       61 tylktkvadv lefpaekdet dteiglswam eqkpdkirif gatggrldhl lanlmmltkp
      121 kflsavpvve midrynyikm ytpgsytiek lpdkkyvaft tmrdvtgltl kgfayplena
      181 typvgsalss nefvgqmgef sfksgmillt qsnd