MULTISPECIES: cell wall metabolism sensor histidine kinase WalK

LOCUS       WP_003722908             610 aa            linear   BCT 10-APR-2024
            [Listeria].
ACCESSION   WP_003722908
VERSION     WP_003722908.1
KEYWORDS    RefSeq.
SOURCE      Listeria
  ORGANISM  Listeria
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae.
REFERENCE   1  (residues 1 to 610)
  AUTHORS   Rao,Y., Peng,H., Shang,W., Hu,Z., Yang,Y., Tan,L., Li,M., Zhou,R.
            and Rao,X.
  TITLE     A vancomycin resistance-associated WalK(S221P) mutation attenuates
            the virulence of vancomycin-intermediate Staphylococcus aureus
  JOURNAL   J Adv Res 40, 167-178 (2022)
   PUBMED   36100324
REFERENCE   2  (residues 1 to 610)
  AUTHORS   Monk,I.R., Shaikh,N., Begg,S.L., Gajdiss,M., Sharkey,L.K.R.,
            Lee,J.Y.H., Pidot,S.J., Seemann,T., Kuiper,M., Winnen,B.,
            Hvorup,R., Collins,B.M., Bierbaum,G., Udagedara,S.R., Morey,J.R.,
            Pulyani,N., Howden,B.P., Maher,M.J., McDevitt,C.A., King,G.F. and
            Stinear,T.P.
  TITLE     Zinc-binding to the cytoplasmic PAS domain regulates the essential
            WalK histidine kinase of Staphylococcus aureus
  JOURNAL   Nat Commun 10 (1), 3067 (2019)
   PUBMED   31296851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 610)
  AUTHORS   Dubrac,S., Boneca,I.G., Poupel,O. and Msadek,T.
  TITLE     New insights into the WalK/WalR (YycG/YycF) essential signal
            transduction pathway reveal a major role in controlling cell wall
            metabolism and biofilm formation in Staphylococcus aureus
  JOURNAL   J Bacteriol 189 (22), 8257-8269 (2007)
   PUBMED   17827301
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF033092.0
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Listeria"
                     /db_xref="taxon:1637"
     gene            1..610
                     /gene="walK"
     Protein         1..610
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /EC_number="2.7.13.3"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /calculated_mol_wt=69387
     Region          6..601
                     /region_name="HK_WalK"
                     /note="cell wall metabolism sensor histidine kinase WalK;
                     NF033092"
                     /db_xref="CDD:467964"
ORIGIN      
        1 mhkmrffqsv qfklvimyll liivamqvig ayfvrelegq leknfqdsit nsitlldyna
       61 reeiiknsdn svklqndire llvdysrass nlievrivdd kgkilgtsnl nnqgivgqks
      121 ndplvkrtls lgttsedkiy kdesnknnrv wvnvssiknk gqvigaiylv adiesvykqv
      181 dditnifitg tliamiitav lgillsrtit kpivemkrqa yamargnysr kvkvygvdei
      241 geladsfntl tkrvqeaqam tegerrklss vlaymtdgvi atdrrgkvil intpaekmlr
      301 vkhesangrs iidvldigdt yqfedlmevd gsltmdrstl dkpyvlranf sviqretgfn
      361 ngviavlhdi tdqekvdqer rdfvsnvshe lrtpltsmhs ylealsdgaw edkeiaprfl
      421 evtqneterm irlvndllkl srmdggreql eksfvnftdf fnhiidrfem mkketimfkr
      481 hiprepviie idedkvmqvl dniisnanky spdggrisfy lkkfedeiev siadeglgvp
      541 dedlanvfdr ffrvdkarsr emggtglgla iarevieahg griwaernkn kgtiikftlp
      601 ysdlpeddwe