MULTISPECIES: thiamine pyrophosphate-dependent dehydrogenase E1

LOCUS       WP_003722498             331 aa            linear   BCT 01-JAN-2025
            component subunit alpha [Listeria].
ACCESSION   WP_003722498
VERSION     WP_003722498.1
KEYWORDS    RefSeq.
SOURCE      Listeria
  ORGANISM  Listeria
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Frank,R.A., Titman,C.M., Pratap,J.V., Luisi,B.F. and Perham,R.N.
  TITLE     A molecular switch and proton wire synchronize the active sites in
            thiamine enzymes
  JOURNAL   Science 306 (5697), 872-876 (2004)
   PUBMED   15514159
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Jordan,F.
  TITLE     Current mechanistic understanding of thiamin diphosphate-dependent
            enzymatic reactions
  JOURNAL   Nat Prod Rep 20 (2), 184-201 (2003)
   PUBMED   12735696
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Hawkins,C.F., Borges,A. and Perham,R.N.
  TITLE     A common structural motif in thiamin pyrophosphate-binding enzymes
  JOURNAL   FEBS Lett 255 (1), 77-82 (1989)
   PUBMED   2792374
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10787196
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Listeria"
                     /db_xref="taxon:1637"
     Protein         1..331
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /EC_number="1.2.4.-"
                     /GO_function="GO:0016624 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, disulfide as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /calculated_mol_wt=36219
     Region          4..328
                     /region_name="AcoA"
                     /note="TPP-dependent pyruvate or acetoin dehydrogenase
                     subunit alpha [Energy production and conversion]; COG1071"
                     /db_xref="CDD:440689"
ORIGIN      
        1 mtlkeaglte dklikmyetm lmarrlderm wllnrsgkip ftisgqgqet aqigaafafd
       61 ldkdyalpyy rdlavvlafg mtakdimlsa fakaedpnsg grqmpahfgq ksnrivtqss
      121 pvttqfphaa giglaakmag deiaiyastg egssnqgdfh eginfasvhk lpvvfvihnn
      181 qyaisvpask qyaaeklsdr aigygipger vdgtnmgevy aafkraadra rngegptlie
      241 tvsyrftphs sddddssyrs reevneakgk dpltifqtel leegylteek iaeiekniak
      301 evneatdyae saayaepess llyvydeean s