chloride channel protein [Listeria monocytogenes].

LOCUS       WP_003722413             408 aa            linear   BCT 21-MAR-2023
ACCESSION   WP_003722413
VERSION     WP_003722413.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 408)
  AUTHORS   Mindell,J.A. and Maduke,M.
  TITLE     ClC chloride channels
  JOURNAL   Genome Biol 2 (2), REVIEWS3003 (2001)
   PUBMED   11182894
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10087035
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..408
                     /product="chloride channel protein"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /calculated_mol_wt=45085
     Region          16..395
                     /region_name="Voltage_gated_ClC"
                     /note="CLC voltage-gated chloride channel. The ClC
                     chloride channels catalyse the selective flow of Cl- ions
                     across cell membranes, thereby regulating electrical
                     excitation in skeletal muscle and the flow of salt and
                     water across epithelial barriers. This...; cd00400"
                     /db_xref="CDD:238233"
     Site            order(79..83,114..118,325..329)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238233"
     Site            order(80,82,116..117,325..327)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238233"
     Site            116
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238233"
     Site            order(161,170,185,192,366,369,377,384,391..392)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238233"
ORIGIN      
        1 mkkvtlifsv ytfilgilvg viaalflamv hfattflwdy lpnqfdfswy yplligligs
       61 ffvgmvqlkl gdyprsmhdn vaeakktgrm eyrkvllpti lsawiiltfg asvgpeaali
      121 givggattwi idhlklsmah keelvslsvg aiissifhap fsglaeeide ssqakkipkn
      181 sklvlsllis fsalgsflwl ksflkmpasi fairlpdmgw swwfillfip tiilgwlfsv
      241 yfqqlqvyia kaasviknkm vaaiigglsi glfgiissfm lfsgehqlie ltttvqnysi
      301 pflliiallk pvlvaiclat gwnggaifpa iftstvmgyi atywidgstg flitvfvtac
      361 ctkivgkpvl tasillfifp lqffpfillt afivnknwwv sirkiira