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LOCUS WP_003722298 357 aa linear BCT 24-DEC-2024 ACCESSION WP_003722298 VERSION WP_003722298.1 KEYWORDS RefSeq. SOURCE Listeria monocytogenes ORGANISM Listeria monocytogenes Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria. REFERENCE 1 (residues 1 to 357) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 357) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 357) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 357) AUTHORS D'Argenio,D.A. and Miller,S.I. TITLE Cyclic di-GMP as a bacterial second messenger JOURNAL Microbiology (Reading) 150 (Pt 8), 2497-2502 (2004) PUBMED 15289546 REFERENCE 5 (residues 1 to 357) AUTHORS Jenal,U. TITLE Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria? JOURNAL Curr Opin Microbiol 7 (2), 185-191 (2004) PUBMED 15063857 REFERENCE 6 (residues 1 to 357) AUTHORS Pei,J. and Grishin,N.V. TITLE GGDEF domain is homologous to adenylyl cyclase JOURNAL Proteins 42 (2), 210-216 (2001) PUBMED 11119645 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10005578 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..357 /organism="Listeria monocytogenes" /db_xref="taxon:1639" Protein 1..357 /product="GGDEF domain-containing protein" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /calculated_mol_wt=39140 Region <12..>149 /region_name="YfhO" /note="Uncharacterized membrane protein YfhO [Function unknown]; COG4485" /db_xref="CDD:443579" Region 82..354 /region_name="GGDEF" /note="GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms]; COG2199" /db_xref="CDD:441801" ORIGIN 1 mveqlvsnaa illagfyiis lvykepitke lstnkkivig iwagllgfal mvfgipisnn 61 vivdlrhipi imvgfyggpi paivsaiiis asrfllsvns aaimaavvmm ligiitaifg 121 kriekfkiwg vfilniiacs fvvinlhlil areshfwinm tvfvlialvi gavsaglmsn 181 mikskqlfqk yeqdstldyl tklsnvrqfd ekinhvmdag srqvtlmlid idyfknindt 241 yghdagdail kqlaiilkrn tsdgseafrn ggeefsivll dcpiekgnff aeqvrretee 301 ydfmipsgqv vkitisvgvs sskdgantse glfksadeal ykakltgrnq vciadgn