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LOCUS WP_003721943 721 aa linear BCT 24-DEC-2024 monocytogenes]. ACCESSION WP_003721943 VERSION WP_003721943.1 KEYWORDS RefSeq. SOURCE Listeria monocytogenes ORGANISM Listeria monocytogenes Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria. REFERENCE 1 (residues 1 to 721) AUTHORS Shalaby,M.W., Dokla,E.M.E., Serya,R.A.T. and Abouzid,K.A.M. TITLE Penicillin binding protein 2a: An overview and a medicinal chemistry perspective JOURNAL Eur J Med Chem 199, 112312 (2020) PUBMED 32442851 REFERENCE 2 (residues 1 to 721) AUTHORS Shaku,M., Ealand,C., Matlhabe,O., Lala,R. and Kana,B.D. TITLE Peptidoglycan biosynthesis and remodeling revisited JOURNAL Adv Appl Microbiol 112, 67-103 (2020) PUBMED 32762868 REFERENCE 3 (residues 1 to 721) AUTHORS Sauvage,E., Kerff,F., Terrak,M., Ayala,J.A. and Charlier,P. TITLE The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis JOURNAL FEMS Microbiol Rev 32 (2), 234-258 (2008) PUBMED 18266856 REMARK Erratum:[FEMS Microbiol Rev. 2008 May;32(3):556] REFERENCE 4 (residues 1 to 721) AUTHORS Zapun,A., Contreras-Martel,C. and Vernet,T. TITLE Penicillin-binding proteins and beta-lactam resistance JOURNAL FEMS Microbiol Rev 32 (2), 361-385 (2008) PUBMED 18248419 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11433609 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..721 /organism="Listeria monocytogenes" /db_xref="taxon:1639" Protein 1..721 /product="peptidoglycan D,D-transpeptidase FtsI family protein" /EC_number="3.4.16.4" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0008658 - penicillin binding [Evidence IEA]" /GO_function="GO:0008955 - peptidoglycan glycosyltransferase activity [Evidence IEA]" /GO_function="GO:0009002 - serine-type D-Ala-D-Ala carboxypeptidase activity [Evidence IEA]" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_process="GO:0009252 - peptidoglycan biosynthetic process [Evidence IEA]" /GO_process="GO:0051301 - cell division [Evidence IEA]" /GO_process="GO:0071555 - cell wall organization [Evidence IEA]" /calculated_mol_wt=79785 Region 36..690 /region_name="FtsI" /note="Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis]; COG0768" /db_xref="CDD:440531" ORIGIN 1 mklnfrkkkk dstkkkraii plrlnilffi ifilfsvlil rlgivqivqg dtykrqleet 61 dnvtvsknvp rgsiydrnyn llvgnsavks itytrsqqtq taetlhvaqt leklitvepe 121 kltdrdlkdy wilthqtesl nrlsakeqal dsskaykiqv dkvtkedias ltsedlkvat 181 iykkmttgya mtesvvknkd vtdeeiarvs enmdslpgvd tttdwnryyt ydetlrsilg 241 svstakeglp kdkaeyylsq gysrndrvgk syleaqyesv lagsksqses vldskgniie 301 tvnkyegskg kdlvlsvdve fqkaveeilq knikqgkqya gsdlfdrafv vamdpysgev 361 lalagqklnd kgefedyslg tfttayamgs avkgstilgg imdgaitnkt vftdqpivlk 421 gtkpksswfn rtgagnrpld pvgaleissn symyqvamkm gganyvpngp lraplstfdd 481 mryyynqfgl gvktgidlpg eqtgykgddq tigkildfai gqydsytplq maqyvstian 541 ggsriapsmv keirnpstng dsvgtlatan epkvlnkigv sesdiktvqq gfyevthgst 601 gtartvftss dydvagktgt adafydgpke gnkmasvwnt tfvgyapvek peiaisvvvp 661 wiyrpygtdq ktnmkiskev fdkyfelkke rseskkdtsk veqpinnkea aakaqseqte 721 n