MULTISPECIES: NAD-dependent epimerase/dehydratase family protein

LOCUS       WP_003124383             316 aa            linear   BCT 02-MAR-2025
            [Pseudomonas].
ACCESSION   WP_003124383
VERSION     WP_003124383.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 316)
  AUTHORS   Thoden,J.B., Hegeman,A.D., Wesenberg,G., Chapeau,M.C., Frey,P.A.
            and Holden,H.M.
  TITLE     Structural analysis of UDP-sugar binding to UDP-galactose
            4-epimerase from Escherichia coli
  JOURNAL   Biochemistry 36 (21), 6294-6304 (1997)
   PUBMED   9174344
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF013530.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF01370.27
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..316
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /calculated_mol_wt=33858
     Region          1..303
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(4,6..7,9,28..30,64..66,108..110,135,139,162..165)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187543"
     Site            order(86,110,135,139)
                     /site_type="active"
                     /db_xref="CDD:187543"
ORIGIN      
        1 mvtgasgfvg salccelart gyaviavvrr vveripsvty ieadltdpat fagefptvdc
       61 iihlagrahi ltdkvadpla afrevnrdat vrlatralea gvkrfvfvss igvngnstrq
      121 qafnedspag phapyaisky eaeqelgtll rgkgmelvvv rppliyanda pgnfgrllkl
      181 vasglplpld gvrnarslvs rrnivgflsl caehpdaage lflvadgedv siaqmieals
      241 rgmgrrpalf tfpavllklv mcllgkasmh eqlcgslqvd askarrllgw vpvetigagl
      301 qaagreyilr qrerrk