MULTISPECIES: MDR family MFS transporter [Pseudomonas].

LOCUS       WP_003115723             501 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_003115723
VERSION     WP_003115723.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024942
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..501
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=52290
     Region          18..421
                     /region_name="MFS_Azr1_MDR_like"
                     /note="Saccharomyces cerevisiae Azole resistance protein 1
                     (Azr1p), and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17502"
                     /db_xref="CDD:341045"
     Site            order(25..26,29..30,33,64,114..115,117..119,122,142,
                     145..146,149,275,278..279,282..284,287,315,319,371..372,
                     376,380,396,399..400,403..404,407)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341045"
ORIGIN      
        1 msdlaqnppa vrtvlaglml siflsaldqt ivavslpais adyadldlla wvisaymvam
       61 tvsmpiygkl gdlygrrrlm lfaivvftaa sllcglaqsm gqlvlarvlq gigagglmav
      121 sqaiigdivp prergryqgy fssmyaiasv agpvlggllt eylswhwvfw inlpigllal
      181 aisrrtlvgl pvprrqpvid ylgivlmvvg ltalllaitq igqgaawsdp allglfalaa
      241 lalllfvaqe rrfreplvpm qlfavraatl swlvaffasf qaisltvlvp lryqsvtgag
      301 adsaalhllp lvmglplgay ccgrltaslg rykplillga vllpcgiagl alvpvgdhwl
      361 sglcmlltgi aigtqfptsl vaaqnaveqr higvatsnat lfrslggavg valmsailla
      421 llkhlriggg ldqgfsesal lssldaasgp arvilqhvla dafkvlflvn aavallglav
      481 asalpdmtlr grgatqptag e